The objective of this study was to assess the association between uric acid and the metabolic syndrome and its components in homozygous sickle cell patients. This is a prospective case/control study of sickle cell SS patients. Each patient was matched to a control of the same sex and age ± 2 years. In our framework, we used the criteria for defining metabolic syndrome according to International Diabetes Federation (IDF) 2009. Assay of all biological parameters was performed with the ARCHITECT ci4100, Abbot (Chicago, Illinois, USA). Data were collected with Excel 2016 software and statistical analysis was done using XLSTAT 2019 software. Student's T test was used to compare means and a p-value less than 0.05 was considered significant. The study population consisted of 100 homozygous sickle cell patients with an average age of 26 years with a sex ratio of 0.58. The prevalence of metabolic syndrome in our population according to the IDF 2009 was 2%. In our study 28% of patients presented with hyperuricemia. Uricaemia was significantly elevated in patients with components of the metabolic syndrome, in particular in 33% of patients with a large waist circumference, in 25% of hypertensive patients, in 50% of patients with hypertriglyceridemia and in 60% of patients with hypertriglyceridemia and low HDL-cholesterol levels. Significant correlations were found between uricemia and certain components of the metabolic syndrome, in particular the level of triglycerides (r = 0.
The relationship between increased body weight and resistance to insulin was studied in a group of 14 healthy men. The reduction in blood glucose and plasma free fatty acid (FFA) levels was measured during one-hour infusions of insulin given in doses which would lead to physiological concentrations of insulin in the plasma.A relationship could not be demonstrated between the blood glucose response and body weight. However, the FFA concentrations fell to lower levels in the leaner than in the heavier subjects, so that a highly significant direct relationship was found between body weight and the post-insulin plasma FFA concentration.The studies therefore show that, over a range of commonly encountered body weights, resistance to insulin develops with increasing fatness. The study also shows that the plasma FFA response to insulin is a more sensitive index of insulin resistance than the blood glucose response.
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