Background: Preconception care is the provision of biomedical, behavioral and social health interventions to women and couples before conception occurs. It aims at improving their health status, and reducing behavioral and environmental factors that contribute to poor maternal and child health outcomes. Therefore, the study was to assess the knowledge on preconception care among reproductive age women. Methods: A descriptive cross-sectional study was carried out amongst 150 reproductive age group women attending the OPD in Manmohan Memorial Teaching Hospital, Kathmandu. The sample was selected by non-probability/purposive sampling technique. Structured questionnaire was used to collect data using interview technique. Data was analyzed via SPSS software version 16. Mean, median and standard deviation was used for analysis of data. Results: The finding showed that 31.3% had adequate knowledge, while 68.7% of the respondents had moderate knowledge about preconception care. Only 40.7% of the respondents knew that folic acid should be started when female discovers that she is pregnant, 36.7% of the respondents knew that folic acid should be started 3 months before conception. While only 24% respondents knew that folic acid is effective in reducing the risk of birth defects. significant association between level of knowledge on preconception care and family income and whereas there was no significant association between the level of knowledge and the age, ethnic group, education level, religion, residence, occupation, type of family, marital status. Conclusions: This study concludes that there was moderate knowledge on preconception care among reproductive age women. Hence, there should be proper counseling and more educational intervention to upgrade the knowledge level of women of reproductive age.

Background: Sickle-cell disease is characterized by a modification in the shape of the red blood cell from a smooth shape into a crescent shape. The misshapen cells lack plasticity and can block small blood vessels, impairing blood flow. The purpose of the study was to find out the quality of life of client living with sickle cell disease. Method: A descriptive cross sectional quantitative study design was used. Non probability convenient sampling technique was used for the selection of respondents after conforming hemoglobin electrophoresis report attending out-patient department of Bheri Hospital. Results: A total 143 participants were studied who were at age range of 19 to 40 years with mean age of 30.26±8.42. Almost 81.8% perceived their health was only fair in comparison to past year. In comparison to other people 60.1% participants believe they get sick little easier. The overall quality of life was good in 56% participants. The health related quality of life scores for eight domains are as follows-physical functioning (77.25±18.22), social functioning (58.39±16.77), role limitation due to emotional problem (57.23±33.99), pain (56.43±22.84), role limitation due to physical problem (49.56±29.76), emotional wellbeing (49.59±14.5), Vitality (36.62±16.85) and general health (36.78±19.99). Conclusion: Quality of life of adults with sickle cell disease is better in the domain of physical function in comparison to other domains. The aspect of energy scale indicates poor quality of life. Female and uneducated clients should be focused for improvement in all domains.