A boy with ichthyosiform erythroderma also suffered from sensorineural deafness, superficial punctate keratitis and acanthosis nigricans. Histopathology revealed basket weave hyperkeratosis, hydropic degeneration of the basal layer, melanin incontinence and moderate mononuclear infiltrate. Typical histological changes were found in clinical lesions of acanthosis nigricans.

A case of dyskeratosis congenita has been documented for the first time in an Indian patient. It began soon after birth with the formation of bullae at traumatic sites, masquerading as epidermolysis bullosa. Nail changes and pigmentary changes appeared simultaneously at the age of 4 years. This seems to be the seventh reported case resulting from a fourth consanguineous marriage.

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This is the sixth case of mutilating palmo-plantar keratoderma, which is characterized by extensive ichthyosis and thickening of skin with accentuated skin markings histologically resembling acanthosis nigricans.

A 45-year-old male patient suffering from borderline lepromatous leprosy with reaction, developed round or irregular, we\1 defined, large tense bu\1ae on existing leprosy lesions. There was deposition of IgG, IgM, IgA and fibrin along the basement membrane. It was not a bu\1ous drug eruption due to either rifampicin, dapsone or clofazimine, but a component of leprosy reaction. Difficulties in classifying as either Type I or Type II reaction are discussed.