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Kefir is a fermented beverage originating form the Caucasian regions composed of a number of bacteria and yeasts living together in polysaccharide grains secreted by them. Kefir can be considered a probiotic source as it presents anti-bacterial, anti-mycotic, anti-neoplasic and immunomodulatory properties. Aiming to appraise a possible anti-inflammatory effect of kefir we conducted cotton-induced granuloma and paw oedema assays in rats, the latter using carrageenan, dextran and histamine as stimuli. Kefir samples were thawed and continuously cultured during 15 days both in a molasses solution (50 g/l) and in cow's milk. A polysaccharide extract isolated from the grains (kefiran) was also tested in cotton-pellet experiments. The results showed significant inhibition in the formation of granuloma tissue for all the test groups, as compared to the blank group. Kefir suspensions in molasses presented an inhibition of 41 +/- 3% for the inflammatory process, fermented milk prepared from kefir showed 44 +/- 6% inhibition and kefiran extract 34 +/- 15%. Rat paw oedema also showed significant decreases with the mediators. Dextran-induced oedema was completely inhibited at 1 h after input, with a 76% inhibition after 2 h. Carrageenan stimulus was inhibited 62% after the 3rd hour, and histamine by 52% after the 2nd hour. These results points to the existence of anti-inflammatory prebiotic compounds present in symbiotic cultures of kefir growing in both aqueous and milky suspensions.

The ozonised sunflower oil, Bioperoxoil, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia coli suspensions using the agar diffusion method. Healing experiments were carried out with Wistar rats through topical application of 3.5 mg/ml of the ozonised oil up to the 7th day after inoculation with S. aureus. Bioperoxoil showed anti-inflammatory effects against all strains tested, with MIC values ranging from 2.0 to 3.5 mg/ml. Bioperoxoil also demonstrated protective effects on skin connective tissue and to enhance wound healing during the treatment, as compared to a neomycin-clostebol association used as a positive control. The overall results indicated a significant antimicrobial activity, anti-inflammatory and wound-healing properties for Bioperoxoil, as compared to other antimicrobial agents commercially available.

A UNIFAL-MG, por meio do Programa de Pós-Graduação em Nutrição e Longevidade (PPGNL) e a Universidade Aberta à Terceira Idade (UNATI), realizou entre os dias 04 e 06 de novembro de 2021, o 1º Congresso Nacional de Nutrição e Longevidade e 3ª Jornada da UNATI. O evento contou com apresentações de trabalhos, mesas-redondas e palestras ministradas por convidados internos e externos. As atividades aconteceram a partir das 17h, com transmissão ao vivo através do canal oficial da UNIFAL-MG no YouTube. Com o objetivo de debater os diferentes aspectos da longevidade e sua relação com a nutrição, assim como questões relacionadas à gerontologia. O público-alvo do evento contou com profissionais de diferentes áreas do conhecimento; graduandos e pós-graduandos. Comissão Organizadora - 1º Congresso Nacional de Nutrição e Longevidade e 3ª Jornada da UNATI - (UNIFAL) Universidade Federal de Alfenas, 2021