γδ T-cell lymphoma is a rare extranodal and systemic neoplasm which accounts for less than 1% of all NHL having peak incidence in adolescents and young adults with a male predominance. Study report two cases, 29 and 25 years male presented with fever, abdominal pain and pancytopenia; one had hepatosplenomegaly while other had marked splenomegaly respectively and both showing feature of hemophagocytosis. Both underwent splenectomy. On gross examination, the spleen was markedly enlarged and shows a deep brown cut-surface. Histologically the normal structure of the spleen is totally effaced by a monotonous lymphoid population consisting of medium-large sized lymphoid cells with vesicular chromatin and small eosinophilic nucleolus with tumor cells showing moderate amount of eosinophilic cytoplasm. Liver biopsy showed regenerative changes in parenchyma and sinusoidal involvement by tumour cells. Peripheral smear revealed atypical lymphocytes with pancytopenia. Bone marrow aspiration showed moderate neoplastic infiltrate by lymphoid cells. Immunophenotypic study showed tumour cells expressing CD3, CD56, CD 2 (dim), TIA-1, TCR-gamma. The tumour cells were immunonegative for CD20, CD5, CD4, CD8, granzyme B, CD7, CD10 and CD 23. Immunophenotypic study is must for diagnosis of γδ T-cell lymphoma which can mimic hemophagocytic syndrome.
The co-existence or concurrent occurrence of brain tumours having different histomorphological features, in the absence of neurofibromatosis central (NF2) or history of irradiation is very rare. Such co-existence of brain tumours with different histology are referred to as collision tumours, concomitant tumours or contiguous tumours. The patient had no history of Von Recklinghausen’s disease nor had any personal or family history of phacomatoses, but, however, he had history of undergoing near total resection of left-sided vestibular schwannoma one year backThe simultaneous occurrence of meningioma and schwannoma is highly uncommon in cerebellopontine angle with only few published cases of co-existing meningioma and schwannoma in patients with no history of neurofibromatosis or other such phacomatoses, albeit this phenomeno of co-existence of these tumours is associated with neurofibromatosis 2 or other phacomatoses. It is also proposed that reactive meningothelial hyperplasia adjacent to the main tumour could be responsible for the presence of meningothelial component within schwannoma
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