Oral delivery of drugs is by far the preferable route of drug delivery due to the ease of administration, patient compliance and flexibility in formulation, etc [1]. The majority of formulations available on the market are oral drug delivery systems. Oral drug delivery systems have developed from immediate release to targeted or site specific delivery over a predefined period. An ideal drug delivery system possess two important characteristics that are with single dose frequency and ability to release the active drug directly at the site of action [2]. Thus, the objective of the pharmacist is to develop systems that release an optimal quantity of drug to a desired site of action. Attempts to develop a single-dose therapy for the whole duration of treatment has lead to the development of controlled or sustained release drug delivery systems.Oral controlled release systems have been developed to achieve optimal drug delivery to the systemic circulation. Although such systems can precisely control the drug release for a prolonged period of time, even over a number of days, some drugs have a narrow absorption window due to them not being absorbed through the gastrointestinal tract, as the dosage formulation will pass through the absorption window. Thus, there was the need to develop a formulation which will prolong the gastric residence time of the system to achieve complete drug release in the gastrointestinal tract (stomach and small intestine) and which will modulate the drug release rate as predicted by the system.Norfloxacin is amongst the most prescribed fluoroquinolone antiinfective for urinary tract infections, prostatitis, gonorrhea and genital tract infection Objectives. The objective of this study was to investigate the effect of release-retarding polymers on the drug release of norfloxacin from floating tablets. Material and Methods. Norfloxacin was procured as a gift sample from Concept Pharma Ltd. Aurangabad (India) and HPMC K100M was procured as a gift sample from Colorcon Asia Pvt. Ltd., Goa (India). The tablets were prepared by direct compression method and various pharmaceutical parameters were evaluated. Results. It was observed that all tablet formulations F1-F9 retained the drug release up to 12 h with good floating property but only Batch-F4 complies with the USP dissolution limits with a minimum floating lag time. The drug release kinetics were evaluated by the model-dependent (curve fitting) method using PCP Disso v3 software shows Batch-F4 shows to best fit with Peppas model for which R2 value was 0.9921 and the release exponent value was 0.6892. Conclusions. The drug release kinetics study indicates that the floating tablets release the drug by diffusion followed by erosion mechanism. Obtained in-vitro drug release data was analyzed by design expert software for drug release at first hour and at 12 th h values and found that release the selected independent variables like HPMC K100M and sodium alginate concentration has a significant effect on drug release (Polim. Med. 2016, 46, 2, 117-127).
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