Present investigation was undertaken with a view to develop fast dissolving tablets of Telmisartan which offers a new range of product having desired characteristics and intended benefits. Fast dissolving tablets of Telmisartan using various superdisintegrants such as Sodium Starch Glycolate (SSG), Crosspovidone (CP) and Crosscarmellose sodium (CCS) were formulated by direct compression method and evaluated for physicochemical parameters, content uniformity, in vitro release and stability studies. All the formulation batches showed drug release in the range of 98.6%-100.6% within 20 min. Disintegration time of all batches was less than 1 min. The best formulation F6 containing 5% CP and 2.5% â-cyclodextrin exhibited 98.8% drug release within 15 min and disintegration time of 13 sec. The formulation F6 was found to be stable at accelerated conditions of temperature and humidity (40 o C and 75% RH). Fast dissolving tablets containing crosspovidone (5%) was found to give best results for in vitro disintegration and dissolution. Moreover, addition of â-cyclodextrin (2.5% w/w) might have enhanced swelling of tablet, thereby decreasing the disintegration time and increased wettability and dispersability of tablets leading to improved dissolution.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.