We
report the synthesis of diblock poly-amido-saccharides (PASs)
by sequential addition of variably protected glucose and galactose
monomers via living anionic ring-opening polymerization. Diblock polymers
with varied polymer length, hydrophobic to hydrophilic ratio, and
stereochemistry of hydrophilic component were synthesized, characterized
by NMR, IR, and GPC. These amphiphilic polymers self-assemble in water
to form nanoparticles as determined by DLS, SEM, and cryo-TEM. Amphiphilic
polymers with glucose-PAS hydrophobic and galactose-PAS hydrophilic
blocks and degree of polymerization of 100 (100-EtGlc1-OHGal3diblock PAS) form
spherical nanostructures and are non-cytotoxic.
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