Blood pressure (BP) monitored within 24 h from the beginning of intravenous thrombolysis (IVT) with alteplase, is one of the important factors affecting the prognosis of patients with acute ischemic stroke (AIS). This study aimed to explore longitudinal BP trajectory patterns and determine their association with stroke prognosis after thrombolysis. From November 2018 to September 2019, a total of 391 patients were enrolled consecutively during the study period, and 353 patients were ultimately analyzed. Five systolic (SBP) and four diastolic blood pressure (DBP) trajectory subgroups were identified. The regression analysis showed that when compared with the rapidly moderate stable group, the continuous fluctuation‐very high level SBP group (odds ratio [OR]: 2.743, 95% confidence interval [CI]: 1.008–7.467) was associated with early neurological deterioration (END). Both the rapid drop‐high level SBP (OR: 0.448, 95% CI: 0.219–0.919) and DBP groups (OR: 0.399, 95% CI: 0.219–0.727) were associated with early neurological improvement (ENI). Moreover, there was a U‐shaped correlation between the OR value of SBP trajectory group and favorable outcome (the modified Rankin Scale [mRS] score 0–2) at 3 months: the slow drop‐low level SBP group represent a well‐established unfavorable outcome risk factor (OR:5.239, 95% CI: 1.271–21.595), and extremely high SBP—the continuous fluctuation‐very high level SBP group, are equally associated with elevated unfavorable outcome risk (OR:3.797, 95% CI: 1.486–9.697). The continuous fluctuation‐very high level DBP group was statistically significant in mRS (OR: 3.387, CI: 1.185–9.683). The BP trajectory groups show varying clinical features and risk of neurological dysfunction. The findings may help identify potential candidates for clinical BP monitoring, control, and specialized care.

Objectives: To investigate the treatment compliance of patients with ischemic stroke to remote ischemic conditioning (RIC) and to determine the factors that influence compliance.Methods: We conducted a retrospective study of patients with ischemic stroke who were treated with RIC. Treatment compliance was determined and analyzed in patients who had received 1 year of RIC training. Factors that influenced patient compliance were also determined using univariate and multivariate regression analyses.Results: Between March 2017 and February 2018, 91 patients were recruited into this study. The mean (±SD) age was 57.98 ± 10.76 years, and 78 (85.7%) patients were male. The baseline Kolcaba comfort scale of patients with good compliance scores were higher than those with poor compliance. The scores of the four dimensions in the scale and the total score are as follows: physiological dimensions, 15.0 (12.0,17.0) vs 17.0 (13.0,19.0); psychological dimensions, 30.0 (25.0,34.0) vs 31.0 (27.0,35.0); sociological dimensions, 20.0 (18.0,24.0) vs 21.0 (18.0,23.0); environmental dimensions, 19.0 (12.0,24.0) vs 20.0 (17.0,22.0); and total points, 82.0 (69.0,94.0) vs 91.0 (78.0,98.0). the differences between the groups were significant (p < 0.05), except for the sociological dimensions. A history of hypertension, number of follow-ups, and the physiological, psychological, and environmental dimensions of the comfort scale were related to patient compliance, out of which the number of follow-ups (Adjusted OR = 2.498, 95% confidence interval (CI) 1.257–4.964) and the physiological discomfort (Adjusted OR = 1.128, 95% CI 1.029–1.236) independently influenced compliance (p < 0.05).Conclusion: In patients with ischemic cerebrovascular disease who were treated with RIC, the number of follow-up visits and physiological discomfort associated with RIC treatment independently influenced patient compliance. Further studies are needed to investigate the RIC protocols and their corresponding nursing models.

Objective: This study aimed to provide a basis for the clinical application of the remotic ischemic conditioning (RIC) by comparing two commonly used doses with the Visual Analogue Scale. Methods: From June to August 2017, 80 healthy adults who were working at the hospital were enrolled in the study. According to the order of enrollment, they were randomly divided into 2 groups by random number method, with 40 subjects in Group1 and Group 2 respectively. The procedure for Group 1 consisted of 3 cycles of simultaneous bilateral upper arm ischemia for 3 minutes followed by reperfusion for another 3 minutes. The procedure was performed by using an electric auto control device with cuffs that inflated to a pressure of 200 mm Hg during the ischemic period. The procedure for Group 2 consisted of 5 cycles of simultaneous bilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes with same pressure. At the same time, the differences of comfort visual analogue scales in the whole process of remote ischemia were observed. Results: The two groups were similar in the age, sex, BMI, and pre-test blood pressure (P0. 05). The comfort of group 2 was significantly lower than that of group 1 during the whole observation period(P0. 05. Conclusions: Subjective comfort was different for subjects with different RIC treatment doses. Subjects with shorter training durations had higher comfort, while higher comfort levels might improve the patient's compliance with RIC treatment.

Objectives: To investigate the treatment compliance of remote ischemic conditioning in patients with ischemic stroke, and determine its associated influencing factors. Methods: A retrospective survey of ischemic stroke patients treated with remote ischemic conditioning was conducted. Treatment compliance was obtained and analysed in patients with one-year training of remote ischemic conditioning. The influencing factors on patients’ compliance were determined by univariate and multivariate regression analysis. Results: The history of hypertension, the number of follow-ups, and the physiological, psychological and environmental dimensions of the comfort scale were related to patient compliance, out of which the number of follow-ups and physiological comfort were independent influencing factors of compliance (P<0.05). Conclusion: In future researches, if we can comprehensively consider the patient’s efficacy, comfort, compliance and other factors, choose the optimal treatment dose, and improve the RIC nursing process accordingly, then this will provide the basis for clinical implementation and scientific research of RIC.

Background: To explore whether longitudinal 24-hour SBP trajectory patterns after thrombolysis could predict the risk of adverse stroke outcome. Methods: The total of 362 ischemic stroke patients, were selected with onset of within 4.5 hours and underwent intravenous(IV) thrombolysis with alteplase(rt-PA). Group-based trajectory models to identify SBP subgroups were used. The demographics, medical history, laboratory test results and the stroke outcome including early neurological deterioration (END), early neurological improvement (ENI), hemorrhage, Barthel index(BI), the modified Rankin Scale (mRS) score, recurrent stroke at 3 months after stroke were collected. Results: The stroke patients with IV thrombolysis were classified into six SBP trajectory groups: admission SBP, antihypertensive drugs before thrombolysis, history of hypertension, stroke, hemoglobin, glucose, and triglycerides. There was no difference in the incidence of hemorrhage, END, and recurrent stroke. The results of logistic analysis,when compared with the moderate-stable SBP group, there was a negative correlation between the risk of ENI and SBP trajectory patterns (OR=0.32; 95%CI: 0.15 to 0.67) , and the “J” correlation between the risk of the mRS score(OR=0.31; 95%CI: 1.50 to 7.30). Conclusion: The findings potentially help identify candidates for clinical blood pressure observation, blood pressure control and nursing care and management.