If a series of chemical substances, extract or new isolated compound available, with no pharmacological history, then blind screening provide clues to potential activity, at least, and preferably, indicates field of activity if exist. The chief purposes of the blind screening are to demonstrate whether the new group of substance is worthy for further attention or not. In the present study, we subjected aqueous extract of date seeds collected from Riyadh for acute toxicity and blind screening to reveal its toxicological and pharmacological data. We used OECD guidelines 425; Up and Down procedure for oral toxicity testing and behavioral profile using Irwin Score for blind screening to get raw data. The extract shown significant increase in alertness, grooming, and restlessness, and spontaneous activity, threshold for pain response, heart rate, urination and decrease in pupil size. The study revealed that date seeds are non toxic with minimum behavioral changes; may be a central nervous system stimulant; antinociceptive and muscarinic; may be a better prototype for further study.
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