Background Psoriasis is a chronic inflammatory skin disease, which holds a high incidence in China. However, professional dermatologists who can diagnose psoriasis early and correctly are insufficient in China, especially in the rural areas. A smart approach to identify psoriasis by pictures would be highly adaptable countrywide and could play a useful role in early diagnosis and regular treatment of psoriasis. Objectives Design and evaluation of a smart psoriasis identification system based on clinical images (without relying on a dermatoscope) that works effectively similar to a dermatologist. Methods A set of deep learning models using convolutional neural networks (CNNs) was explored and compared in the system for automatic identification of psoriasis. The work was carried out on a standardized dermatological dataset with 8021 clinical images of 9 common disorders including psoriasis along with full electronic medical records of patients built over the last 9 years in China. A two‐stage deep neural network was designed and developed to identify psoriasis. In the first stage, a multilabel classifier was trained to learn the visual patterns for each individual skin disease. In the second stage, the output of the first stage was utilized to distinguish psoriasis from other skin diseases. Results The area under the curve (AUC) of the two‐stage model reached 0.981 ± 0.015, which outperforms a single‐stage model. And, the classifier showed superior performance (missed diagnosis rate: 0.03, misdiagnosis rate: 0.04) than 25 Chinese dermatologists (missed diagnosis rate: 0.19, misdiagnosis rate: 0.10) in the diagnosis of psoriasis on 100 clinical images. Conclusions Using clinical images to identify psoriasis is feasible and effective based on CNNs, which also builds a solid technical base for smart care of skin diseases especially psoriasis using mobile/tablet applications for teledermatology in China.
Many state-of-the-art general object detection methods make use of shared full-image convolutional features (as in Faster R-CNN). This achieves a reasonable test-phase computation time while enjoys the discriminative power provided by large Convolutional Neural Network (CNN) models. Such designs excel on benchmarks 1 which contain natural images but which have very unnatural distributions, i.e. they have an unnaturally high-frequency of the target classes and a bias towards a "friendly" or "dominant" object scale. In this paper we present further study of the use and adaptation of the Faster R-CNN object detection method for datasets presenting natural scale distribution and unbiased real-world object frequency. In particular, we show that better alignment of the detector scale sensitivity to the extant distribution improves vehicle detection performance. We do this by modifying both the selection of Region Proposals, and through using more scaleappropriate full-image convolution features within the CNN model. By selecting better scales in the region proposal input and by combining feature maps through careful design of the convolutional neural network, we improve performance on smaller objects. We significantly increase detection AP for the KITTI dataset car class from 76.3% on our baseline Faster R-CNN detector to 83.6% in our improved detector.
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