Anthelmintic activity of Annona crassiflora leaves against Haemonchus contortus: part 1: in vitro inhibition of the hatchability and larval development [Atividade antihelmíntica de folhas de Annona crassiflora contra Haemonchus contortus: parte 1: inibição in vitro da eclodibilidade e do desenvolvimento larval] "Scientific Article/Artigo Científico"
In this study we evaluated the oral toxicity of leaf extracts of Annona crassiflora of for mice and the blood and parasitological parameters of lambs experimentally infected with Haemonchus contortus and treated with leaves of this plant. The highest dose of AE (aqueous extract) administered to mice (203.0 mg/kg bw) was well tolerated, suggesting low toxicity. At necropsy, macroscopic examination revealed no abnormalities of the evaluated viscera. Lambs infected with the nematode were divided one group treated with leaf powder and a control group that did not treat. Split-plot design analysis was performed where the treatments were defined as plots and three periods of collection were defined as subplots. Similar performances to weight gain were observed among the lamb groups. The oral administration of leaf powder at 2.75g /Kg bw did not alter the physiological blood parameters in comparison to untreated lambs; however, this dose was not efficient to fecal egg reduction. We consider that other formulations and administration protocols should be evaluated to promote an effective alternative control using the leaves of this plant.
The aim of this study was to evaluate the effect of Mangifera indica leaf hay on the control of Haemonchus contortus in lambs, Sixteen crossbred Santa Inês x Dorper lambs were divided into two homogeneous groups. One group was provisioned with 5g of leaf hay /Kg of body weight (BW) and other was not with the hay of this plant.On the 21st day, the animals of both groups were inoculated with infective larvae from H. contortus. The growth, intake and performance for animals were evaluated before and after the nematode infection. Lamb blood parameters were analyzed before the hay administration (day − 14), when the animals receiving the hay and were not-infected (day 7) and when receiving the hay and were infected with H. contortus (day 30). The faeces were collected on day 42, 44, 46, and 48 of the experiment to quantify the eggs per gram of faeces (EPG). The body weight gain was lower when the animals were infected to both groups. In the second period, the animals fed with the hay of M. indica showed higher feed efficiency than the un-treated group. The eosinophil concentrations were higher in the last two periods evaluated. However, the EPG averages were similar between lamb groups. Thus, the inclusion of hay from M. indica leaves in the lamb feed can lead to an improvement in feed efficiency of the animals infected with H. contortus. It can also increase their eosinophil concentration, which in turn could improve tolerance to the nematode infection.
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