Vertebrate embryogenesis is a remarkable process, during which numerous cell types of different lineages arise within a short time frame. An overwhelming challenge to understand this process is the lack of dynamic chromatin accessibility information to correlate cis-regulatory elements (CREs) and gene expression within the hierarchy of cell fate decisions. Here, we employed single-nucleus ATAC-seq to generate a chromatin accessibility dataset on the first day of zebrafish embryogenesis, including 3.3 hpf, 5.25 hpf, 6 hpf, 10 hpf, 12 hpf, 18 hpf and 24 hpf, obtained 51,620 high-quality nuclei and 23 clusters. Furthermore, by integrating snATAC-seq data with single-cell RNA-seq data, we described the dynamics of chromatin accessibility and gene expression across developmental time points, which validates the accuracy of the chromatin landscape data. Together, our data could serve as a fundamental resource for revealing the epigenetic regulatory mechanisms of zebrafish embryogenesis.
Bismuth vanadate (BiVO4) has been widely applied as photoelectrode material, while its insufficient charge separation and utilization efficiency have been the major obstacle in photoelectrochemical (PEC) water oxidation. Herein, a...
A well-known bottleneck of contemporary mobile devices is the inefficient and error-prone touchscreen keyboard. We have developed UbiK, an alternative portable text-entry method that allows user to type on a piece of paper, placed on solid surfaces like wood desktop. UbiK leverages the microphones on a mobile device to accurately localize the keystrokes through fine-grained acoustic fingerprinting. We have implemented UbiK as an Android application. Our experiments demonstrate that UbiK is able to achieve above 95% of localization accuracy. In this demonstration, we will show how Ubik works with an external paper keyboard ( Figure 1) for a smartphone and a 7-inch tablet. User participation will be welcome in this live demo.
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