A new commercial-scale alternative
manufacturing process to produce
a complementary source of artemisinin to supplement the plant-derived
supply is described by conversion of biosynthetic artemisinic acid
into semisynthetic artemisinin using diastereoselective hydrogenation
and photooxidation as pivotal steps. This process was accepted by
Prequalification of Medicines Programme (PQP) in 2013 as a first source
of nonplant-derived-artemisinin in industrial scale from Sanofi production
facility in Garessio, Italy.
M.W. (2015) 'Applying green chemistry to the photochemical route to artemisinin.', Nature chemistry., 7 (6). pp. 489-495. Further information on publisher's website:https://doi.org/10.1038/nchem.2261Publisher's copyright statement:Additional information:
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