Naturally occurring collagenofibrotic glomerulonephropathy was found in an intact male cynomolgus monkey at 4 years and 5 months of age. Clinical examination showed mild proteinuria and hypoproteinemia, and the kidneys were macroscopically pale and granular on the surface. Histopathology revealed diffuse panglomerular swelling with the accumulation of eosinophilic amorphous material that was negative for amyloid staining and periodic acidSchiff, but positive for collagen fibers by Mallory-azan staining in the glomerular capillary wall and mesangial area. Immunohistochemistry revealed a strong positive reaction with anti-type III collagen antibody in the glomeruli. The mesangial area was widened, but there was no increase in the number of mesangial cells. No lesion was observed in the efferent/afferent arterioles or other arteries. Mild tubular degeneration was observed in the cortex, occasionally with cholesterin crystals and interstitial lymphocytic infiltration. Electron microscopy revealed various-sized collagen fibrils with typical banding periodicity in the subendothelial space and the mesangial area. The present case offers information on spontaneous and life-threatening primary glomerular fibrosis in a young monkey suggesting an idiopathic familial disease similar to those observed in humans. (J Toxicol Pathol 2004; 17: 279-282)
Iron lactate was given to Sprague-Dawley rats intravenously at the dosage of 10 mg/kg/day and the early effects on the parathyroid gland were examined ultrastructurally along with the blood level of parathyroid hormone (PTH) after single, 3-day or 6-day administration. Blood levels of electrolytes and other parameters related to osteoclast dynamics were also measured by blood chemistry and histopathology. The plasma parathyroid hormone (PTH) level was elevated in the single and 3-day dosing group but was reduced in the 6-day dosing group. Histopathologically, an increase of osteoclasts in the primary spongiosa was observed in the 3- and 6-day dosing groups. Image analysis of the parathyroid gland revealed that the average area of the storage granule decreased during a experimental period, with the number of storage granules decreasing in the 3- and 6-day dosing group. The chief cells of the parathyroid gland were moderately atrophied in the 6-day dosing group. These results demonstrate that iron lactate immediately promotes discharge of PTH from the storage granules after the treatment and induces an increase of osteoclasts in the primary spongiosa. The findings collectively suggest a pathophysiological mechanism of iron lactate-induced osteopenia in rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.