Hill for technical assistance; to Dr. Curtis B. Thorne for supplying the anthrax ancigens and horse sera; to Mr. Ralph G. Kanode, Jr,, for permitting duplication of the reading apparatus and to Mr. Frank D. Belton, M.R.E. Laboratories, Porton, England, for submitting serum samples. ABSTRACTA modification of the agar/gel precipitin inhibition technique of Thorne and Belton I for detecting anthrax antibodies reduces inconsistency of visually determined end points on the same sera observed by different technicians.Determination of the minimum reacting concentrations of the anthrax antigen and antibody reagents, modifications of the visualization apparatus, methods for combining reagents, and length of incubation periods contributes to the ease of the end point determinations and the uniformity of results.When compared with the previous technique, the modified procedure is less time-consuming and retains satisfactory reproducibility, simplicity, specificity, and sensitivity.
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