Background
Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that can change a patient's quality of life and impair their daily activities. Non-alcoholic fatty liver disease (NAFLD), on the other hand, has become a widespread condition as the global obesity rates rises. The prevalence of NAFLD has reached up to 25% of the adolescent population. The etiology of both diseases is still not clearly understood. The mechanism linking the two seemingly similar diseases could be immune system activation and tissue inflammation; thus, the goal of our study was to see if there was a common link between them and to examine NAFLD prevalence and severity in IBS patients. Our study included 150 patients who have symptoms of IBS with different degrees of severity. IBS was diagnosed according to modified ROME IV criteria. Patients were examined to see if they had NAFLD based on abdominal ultrasonography and NAFLD fibrosis score calculation.
Results
Our current study showed that regarding evaluating the association of IBS with NAFLD, there was a highly statistically significant association between both diseases. Furthermore, there was a high statistical significant association between higher grades of NAFLD and lipid profile parameters.
Conclusion
Patients with IBS had a higher frequency of NAFLD. In addition, a significant association was noted between IBS severity and increased NAFLD grades.
BackgroundIrritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disease that can change a patient's quality of life and impair their daily activities. Non-alcoholic fatty liver disease (NAFLD), on the other hand, has become a widespread condition as the global obesity rates rises. The prevalence of NAFLD has reached up to 25% of the adolescent population. The etiology of both diseases is still not clearly understood. The mechanism linking the two seemingly similar diseases could be immune system activation and tissue in ammation; thus, the goal of our study was to see if there was a common link between them and to examine NAFLD prevalence and severity in IBS patients. Our study included 150 patients who have symptoms of IBS with different degrees of severity. IBS was diagnosed according to modi ed ROME IV criteria. Patients were examined to see if they had NAFLD based on abdominal ultrasonography and NAFLD brosis score calculation.
ResultsOur current study showed that regarding evaluating the association of IBS with NAFLD, there was a highly statistically signi cant association between both diseases. Furthermore, there was a high statistical signi cant association between higher grades of NAFLD and lipid pro le parameters.
ConclusionPatients with IBS had a higher frequency of NAFLD. In addition, a signi cant association was noted between IBS severity and increased NAFLD grades.
Background: The presence of an elevated absolute polymorphonuclear leukocyte count in the ascitic fluid (>250 cells/mm3) in combination with a positive ascitic fluid bacterial culture is diagnostic of spontaneous bacterial peritonitis. Among the families of calcium-binding proteins known as S100, calprotectin belongs to the subfamily known as calgranulins. Objective: The aim of the current work was to examine the value of ascitic fluid calprotectin for the diagnosis and prognosis of spontaneous bacterial peritonitis in people with liver cirrhosis. Patients and Methods: Between April 2018 and May 2019, 50 Egyptians with liver cirrhosis and ascites were recruited. Forty individuals with spontaneous bacterial peritonitis (SBP) and 10 patients with ascites without SBP were studied. Biochemical, bacterial, and ascitic calprotectin level, as well as diagnostic paracentesis, were performed to all patients. Results: When comparing individuals with cirrhosis and SBP to those without SBP, the level of calprotectin in the ascitic fluid was significantly higher in SBP patients (P= 0.000). Its mean values were statistically significantly reduced after treatment of SBP in comparison to its level before treatment [reduced from 626.75 ± 188.05 to 251.25 ± 223.13 ug/l] with p value 0.000. At a cutoff value of >320 ug/l, ascitic calprotectin may be a possible marker of development of SBP among cirrhotic patients with ascites with 95% sensitivity and 90% specificity. Conclusion: It could be concluded that ascitic fluid calprotectin may be useful in the diagnosis and prognosis of patients with liver cirrhosis and spontaneous bacterial peritonitis.
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