To examine the effect of exercise on NAFLD biomarkers including aspartate transaminase (AST), alanine transaminase (ALT), and gamma-glutamyl transferase (GGT); triglycerides (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL); and glucose (GLU) and insulin (INS). METHODS: We searched five electronic databases to identify randomized controlled trials that: 1) included adults with NAFLD; 2) had an aerobic (AE) and resistance (RE) exercise intervention alone or combined (CE) without dietary or pharmacological intervention; 3) included a non-exercise control group; 4) reported > 1 NAFLD biomarker pre-and post-intervention, and 5) were published in English. The pooled Hedge's g effect size (ES) of the postminus pre-intervention change versus control for each NAFLD biomarker was calculated with a random effects model in STATA with significance p<0.05, and then back converted to the original unit for clinical interpretation. RESULTS: Of 263 potential studies, 18 qualified that included 795 middle aged (50.7±6.3yr) adults (56% men) with obesity (32.1±3.7kg/m2). Subjects had an intrahepatic triglyceride TG content ranging from >5% to 12%. AE (n=405), RE (n=67) or CE (n=43) were performed at moderate to vigorous intensity 3.5±0.9d/wk for 42.7±9.9min/session for 14.
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