Background: As per Ayurvedic classics apeenasa is one of the nasagata rogas (nasal disorders) that be considered as the paranasal sinusitis according to the conventional medicine. The terms peenasa and apeenasa can be used based on the stages and the types of paranasal sinusitis. Objectives: To evaluate the efficacy of nasya karma (nasal instillation therapy) and vyoshadi vati in patients of apeenasa having nasasrava (nasal discharge), shirogurutwa (heaviness of head) and kshavatu (sneezing) of patients suffering from apeenasa. Design: This was a randomized controlled study with thirty patients divided into three groups, 10 in each. In Group A, Nasya karma was given once a day for 7 days, in Group B, Vyoshadi vati was given twice a day for 7 days and in Group C, Nasya karma and Vyoshadi vati was given in combination for 7 days. Results: Statistically significant results were seen in reduction of nasasrava, shirogurutwa and kshavatu of patients suffering from apeenasa with p<0.001. Conclusions: Group C (Nasya karma with vyoshadi vati) showed statistically significant results compared to Group A (nasya karma) and Group C (Vyoshadi vati) in reduction of nasasrava, shirogurutwa and kshavatu of patients suffering from apeenasa.
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