The present investigation aims to synthesize 11 compounds of quinazoline-1 derivatives and to test their antimicrobial and anti-HIV1 activities. A quick-witted method was developed for the synthesis of novel substituted quinazolinone derivatives by summarizing diverse diamines with benzoxazine reactions, and it demonstrated the benefits of typical reactions, handy operation, and outstanding product yields. These compounds were confirmed by elemental analysis, I R, 1H NMR, 13C NMR, and mass spectra. Then antimicrobial and anti-HIV1 activities of the compounds were tested in-vitro. It was found that compounds 7–11 possessed a wide range of anti microbial and anti-HIV1 activity.

No abstract

Theileriosis is an important haemoparasitic disease of goats which causes serious economic losses to farmers. There is a paucity of information on the clinico-haemato-biochemical aspects of caprine theileriosis in Kerala. The present study was undertaken to evaluate the haemato-biochemical alterations associated with clinical cases of caprine theileriosis in twenty five smear positive goats in Thrissur district, Kerala. Major clinical signs observed were anaemia, fever, lymphnode enlargement, anorexia, respiratory distress. Haemato-biochemical analysis revealed macrocytic hypochromic anaemia with low Hb, Volume of Packed Red Cells (VPRC), platelet, Total Erythrocyte Count (TEC) and hyperproteinaemia with hyperglobulinaemia in the affected goats.

A B S T R A C TThis study investigated the colour removal efficiency of Rhodamine B (RhB) by electrochemical oxidation. The influences of various operating variables such as current density (from 5 to 25 mA/cm 2 ), initial concentration of dye solution (from 50 to 250 mg/L), initial pH of solution (3,5,7,9), the stirrer speed (150-300 rpm) and the concentration of electrolytes (0.025-0.10 M NaCl) on removal efficiency were explored in a batch mode treatment to achieve a higher removal capacity. The results obtained with synthetic wastewater revealed that the most effective removal of dye could be achieved when the pH was kept neutral. The results showed that the colour removal increases with the increase in applied current density, NaCl concentration, while it was found to decrease with the increase in initial dye concentration. The complete (100%) colour removal has been achieved under the optimal experimental conditions such as NaCl concentration of 0.05 M, applied current density of 15 mA/cm 2 , initial pH 7.0, stirrer speed of 200 rpm and electrolysis time of 40 min. The result of UV-vis spectrum analysis confirms the removal of colour from RhB aqueous solution at the short treatment time. In addition, the increase of current intensity, in the range of 0.6-2.0 A, enhanced the treatment rate. The method was found to be highly efficient and relatively fast compared to conventional treatment techniques.