SUMMARY The intragastric infusion of red chilli powder in dosage of 1.6 and 0X8 g/hr caused a marked increase in the DNA content of the gastric aspirate compared with basal values for DNA. This observation suggests a rapid and marked exfoliation of gastric surface epithelialcellsinhuman subjects given red chilli powder.The surface epithelial cells of human gastric mucosa are continuously exfoliated. Since the deoxyribonucleic acid (DNA) content in each of these somatic nuclei is identical, the measurement of the DNA content in gastric aspirate over a fixed period of time indicates the rate at which gastric surface epithelial cells are extruded (Croft, Pollock, and Coghill, 1966). Drugs such as aspirin and phenylbutazone were shown to cause increased exfoliation of surface epithelial cells in dogs (Max and Menguy, 1970).
The DNA content in gastric aspirate was measured before and during intragastric infusion of 0.1 or 0.2 g/hr tobacco powder. The infusion of 0.1 g/hr caused an insignificant rise in the DNA content but infusion of 0.2 g/hr of tobacco caused a marked and rapid rise in the DNA content of gastric aspirate during the hour of infusion. The effect of tobacco was transient (ie, only during the period of infusion). These observations indicate that the increased exfoliation of surface epithelial cells of human gastric mucosa with tobacco infusion is dose related.
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