The work is devoted to the analysis of world literature for a period of more than 30 years. It reflects the data on the combined treatment of brain metastases and the nature of the occurrence of pathomorphological changes in cells of irradiated intracranial neoplasms (mostly benign or obtained on experimental models, including using electron microscopy). The nature of pathomorphological changes in cells of irradiated brain metastases is not described in world literature. The paucity of literature data indicates the need for a detailed study of the nature of pathomorphological changes in the tissues of irradiated metastases after radiosurgery, which should ultimately improve the quality of care for oncological patients with brain metastases.
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