SUMMARY :An experiment was conducted to evaluate the flowering and vase life performance of standard chrysanthemum cultivars in naturally ventilated polyhouse condition. Among five standard chrysanthemum cultivars Snow ball recorded maximum plant height (115.79 cm), early flower bud initiation (83.50 days), flower stalk length (96.72 cm), flower diameter (14.08 cm) whereas cv. CHANDRAMA recorded maximum flower stalk girth (11.20 mm) and weight of cut stem (156.99g). The maximum vase life (14.00 days) was observed by cv. GOLDEN YELLOW in vase life solution of sucrose (2 %) + 8HQC (500 ppm). The maximum fresh weight ( 76.53 g) was recorded by cv. CHANDRAMA on second day. Snow Ball recorded maximum (11.76 g) transpiration loss of water on day 1-2 whereas the maximum (9.48 g) water uptake was noted by cv. SNOW BALL on day 0-1 followed by Angel Pink (6.82 g).How to cite this article : Siddiqua, Asma, Lakshmi, K. Swarajya, Nagaraju, R., Reddy, D. Srinivasa and Shaheda, S. (2017). Flower quality parameters and vase life studies of standard chrysanthemum cultivars (Dendrathema grandiflora Tzvelev) in polyhouse conditions. Agric. Update, 12(TECHSEAR-3) : 692-696;
Cancer is definitely one of the leading causes of mortality worldwide. Failure in the efficacy of the standard treatments (chemo-, radiotherapy and surgery), and the severe side effects, resistance of tumor cells to chemotherapeutics have necessitated alternative therapeutic strategies. Magnetic nanoparticles (MNPs) have been assessed as potential cancer therapy materials. Their intrinsic magnetic properties provide a cancer detection, monitoring, and therapy platform based on multimodal theranostics. MNPs can be functionalized by binding them to a wide variety of substances, including chemotherapeutic drugs, radionuclides, nucleic acids, and antibodies. They can be used for drug delivery, magnetic or photothermal induced local hyperthermia and photodynamic therapy aimed at killing cancer cells at the tumor site. MNPs may also be useful to challenge drug resistance. The combination of different options of these treatment modalities offers a synergistic effect and significantly reduces the side effects. The functionalized MNPs may be used to remove the unwanted cells from blood, including leukemia cells and circulating tumor cells that key factors in the metastatic process. Despite numerous successful studies, there are still some unpredictable obstacles relevant to the use of MNPs in cancer therapy. This review mainly focuses on the application of MNPs in cancer treatment, covering future perspectives and challenges aspects.
Objective: The present investigation aims to formulate the ideal drug formulation using different surfactants and optimize the amlodipine-loaded polymeric nanoparticles.
Methods: The present work was to formulate the drug-loaded polymeric nanoparticles to enhance the dissolution rate of a poorly water-soluble drug, amlodipine besylate, using the anti-solvent precipitation method. The Characterisation studies include particle size (nm), Zeta potential (mV), polydispersity index, Drug entrapment efficiency (%), in vitro release drug release, and surface morphological studies like SEM and XRD.
Results: The drug-loaded Polymeric nanoparticles of F3 containing PLGA and PVA shows the desired smaller particle size is 198.8±5.25, maximum zeta potential is-24.76±2.54 mv and the stable polydispersity index of 0.957±0.45. The drug entrapment efficiency is 93%, and the controlled dissolution of the ideal formulation pattern is about 94.88±2.45 in 24h.
Conclusion: The release pattern observed that PNs significantly improved the dissolution character of amlodipine besylate. PNs have a controlled drug release pattern and can be used as a suitable drug delivery carrier for low solubility and poorly bioavailable drugs like amlodipine to improve its dissolution rate.
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