Bioinformatics applications are generally multi-server dependants and will have to communicate several information repositories to carry out any analyses. These applications remain computationally intensive and time consuming as they engage lots of data transfer. Hence they face a major bottleneck when ported as web applications. Browser based web applications normally feature the classical request-response approach. If the response becomes late, as it is expected to happen in the case of long running Bioinformatics programs, Apache will get tired and a request timeout error might occur. Alternate approaches like "Client-Pull" models that involve polling strategy with the unpredictable amount of page refreshes, only tend to intensify the network traffi c. Hence a technology that is intelligent enough to support the varied exhaustive Bioinformatics processes becomes highly essential. In this review, we propose how AJAX can afford a laconic framework within the Bioinformatics applications to completely reduce the page refresh nuisance and provide a better user experience.
AIM-BLAST, AJAX Interfaced Multisequence Blast, is a simplifi ed tool developed to facilitate the multiple sequences blast using AJAX as an interface. This tool has been integrated with the SOAP services of EBI NCBI Blast and the functionality of AJAX (Asynchronous Javascript and XML), so as to minimize the enormous bandwidth consumption while carrying out blast analysis for many sequences at an instance. Although a few tools for multiple sequences blast are already available online, they are restricted only to a limited number of genomes and consume several bytes of data transfer for receiving the results. Further, AIM-BLAST also has enhanced features for automated parsing of the Blast results of individual sequence and presenting them as "one sequence-one function" manner. This will save the users time and effort in interpreting the bulky blast results to identify one suitable hit. The results of the blast search in this tool are displayed in an easily interpretable table format that makes the tool user-friendly too. Hence this tool, with a laconic framework, will remain a well structured, fl exible and a highly controlled Blast Program for investigating numerous sequences at a stretch with the consumption of reduced level of data transfer.Availability: AIM-BLAST is freely available at http://biotool.nrcfosshelpline.in/aimblast/
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