Background: A woman's reproductive period begins at menarche and ends in menopause. It usually extends from 13 to 45 years. Many physiological and hematological changes do occur during the pregnancy period and after delivery. Aims and Objectives: The present study was done to evaluate the variations in red blood cell (RBC) and white blood cell (WBC) counts before and after normal vaginal delivery. Materials and Methods: A hospital-based cohort study conducted on 500 pregnant females who got admitted to labor room for delivery at McGann Teaching District Hospital, Shivamogga. Blood samples were taken during the time of their admission to labor ward and within 12-24 h after normal vaginal delivery and the cell counts were estimated using Sysmex KX-21 automated hematology analyzer. Results: The mean values of RBC count before delivery were found to be 4.4 millions/mm 3 with standard deviation of ±0.5 which dropped to 4 millions/mm 3 with standard deviation of ±0.5 on the 1 st day of puerperium. The mean values of WBC count before delivery were found to be 12,495.6 cells/mm 3 with standard deviation of ±3663.5 cells/mm 3 which increased to 16,027 cells/mm
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