Introduction Coronavirus disease 2019 (COVID-19) vaccine hesitancy amongst healthcare workers (HCW) has been reported in varying degrees in different parts of the world. In this study, we investigate the degree of vaccine hesitancy amongst HCWs and factors associated with it during the second wave of the pandemic in our centre. Methods We undertook this single-centre, cross-sectional study in an urban tertiary care hospital, using a modified Oxford COVID-19 vaccine hesitancy scale. We performed descriptive and appropriate univariate analysis. We used the Kruskal Wallis test as appropriate, and Spearman rank correlation to evaluate the relation between general attitude to vaccination and COVID vaccine hesitancy score. Results We obtained 223 responses. The majority of HCWs in our sample (n = 201; 90.1%) had received at least one dose of the vaccine. The mean (SD) Oxford vaccine hesitancy score was 28.54 ± 2.05, with no significant difference observed between doctors (28.45 ± 2.26) and nurses (28.68 ± 1.70), or across different specialities. Of the respondents, 92.7% (n = 216) responded positively to taking the vaccine. The lack of dependents at home was the only significant contributor to vaccine hesitancy. Age, gender, marital status, and COVID-19 infection status did not significantly affect vaccine hesitancy. Conclusion We found a significantly lower degree of hesitancy towards COVID-19 amongst HCWs in our centre during the pandemic’s second wave. A more comprehensive and multi-centric study is required to validate this finding.

Introduction: Blood stream infections are very common in the pediatric age group. Patients with bacteremia may have either a transient bacteremia that may be rapidly and permanently cleared by a patient's host defenses with no major consequences, or persistent bacteremia which can be self-limited without development of focal infection or sequelae, or may progress to a more serious fatal infection or toxic symptoms. Objectives:The aim of our study is to analyze the hospital data on bacteremia in children less than 10 years with special reference to male and female cases, the pathogens involved, and the antibiotic susceptibility patterns. Methods:Over a one year period samples were collected from 128 children who included all newborn babies and children admitted with fever and suspected of having sepsis. Blood was collected depending upon age groups with aseptic precaution and incubated at 37 o C for 10 days. Subcultures were made on blood agar and MacConkey agar plates. Organisms were identified and antibiotic sensitivity test of the isolates were performed.Results: Out of 128 suspected cases, 32 (25%) was culture positive. Male to female ratio is 1.28:1.0. Klebsiella species (43.75%) was the most common organism isolated followed by Staphylococcus aureus (18.75%). Prevalence of gram negative organism was 71.87%. Most of the gram negative organisms showed maximum resistance to ampicillin and the gram positive organisms to penicillin. In this study three gram negative organisms were extended-spectrum beta lactamases (ESBLs) producers and one Pseudomonas aeruginosa was metallo-beta lactamase (MBL) producer. 33.33% of staphylococcus aureus was Methicillin resistant Staphylococcus aureus (MRSA) strains. Interpretation and Conclusion:This study showed a 25% prevalence rate of bacteremia among children with an increasing prevalence in the age group of 5-10 years and also an observed decline in susceptibility of the pathogens to common antibiotics which ultimately stresses on the need for continuous screening and surveillance for antibiotic resistance in the pediatric care unit and calls for increased efforts to ensure more rational use of these drugs.

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Introduction: Ventilator-associated pneumonia (VAP), an important form of hospital-acquired pneumonia (HAP), specifically refers to pneumonia developing in a patient on mechanical ventilator for more than 48 h after intubation or tracheostomy. Despite the advancements in antimicrobial regimes, VAP continues to be an important cause of morbidity and mortality. VAP requires a rapid diagnosis and initiation of appropriate antibiotic treatment, as there is adverse effect of inadequate antibiotic treatment on patients' prognosis and the emergence of multidrug-resistant (MDR) pathogens.Aims: The present study was undertaken to assess the etiological agents of early-onset and late-onset VAP and to know their sensitivity pattern. Material and Methods:VAP data over a period of 12 months (February 2012 -February 2013 in a tertiary care ICU was retrospectively analysed. The patients were stratified by age, sex, duration of VAP (Early/Late onset) and the identified pathogens with their sensitivity pattern.Results: Incidence of VAP was found to be 35.14%, out of which 44.23% had early-onset (<4 days MV) VAP and 55.77% had lateonset (>4 days MV) VAP. The most common organisms isolated in early onset and late onset VAP was Pseudomonas aeruginosa, E.coli and Acinetobacter baumanii. All enterobacteriaceal isolates were extended spectrum beta lactamase (ESBL) producing organisms and all Staphylococcus aureus isolates except one were methicillin resistant. The incidence of Multidrug resistant (MDR) Pseudomonas aeruginosa and Acinetobacter were 40% and 37.5% respectively.Conclusion: Due to the increasing incidence of multidrugresistant organisms in our ICU, early and correct diagnosis of VAP is an urgent challenge for an optimal antibiotic treatment and cure. Hence, knowing the local microbial flora causing VAP and effective infection control practices are essential to improve clinical outcomes.

Background: The quality of life can be improved by enhancing the standards of the medical treatment at all levels of the healthcare delivery system. A medical audit oversees the observance of these standards. Prescription Audit offers the most comprehensive overview of performance, detailing parameter as per the check list of prescription audit. Aim: To monitor, evaluate and suggest modifications (if necessary) in the prescribing practices of medical practitioners. Methods: The observational study was conducted over a period of 6 months and data were collected from 1093 prescriptions collected from outpatient department of a tertiary care teaching hospital in India. Results: Total 1093 prescriptions were evaluated for the Audit, out of which 56.4% were Male & 43.6% were Female cases. Majority of the study subjects belonged to the age group of 40-59 years (32.4%). During the study mainly twelve parameter were assessed according to the checklist provided by the Hospital with total 1093 samples of prescription audit, only 2.2 % (280) cases had the non-compliance, 64.5% (8464) cases had compliance and 33.3% (4372) not applicable to this parameters. Conclusion: The results obtained from the study shows the prevailing prescribing habits at our institution. Many of the prescribing trends from this study are a cause of concern and need attention. This study reveals that the auditing of prescription in terms of rationality, it remains poor. The value of such audits in generating and testing hypotheses on inappropriate prescribing will definitely create an intervention to improve prescribing habits and ultimately patient care will be improved.