Background: The concept of formulating ODT containing montelukast sodium offers an appropriate, practical approach to accomplish fast release of the drug. Absorption of these tablets takes place directly into the systemic circulation which bipass the hepatic first-pass metabolism of montelukast sodium which ultimately results in the improvement in the bioavailability.
Method: In the present study ODT tablets of montelukast sodium were prepared by using different Superdisintegrants like natural and synthetic (tulasi, hibiscus, orange peel powder, Ispaghula, banana peel powder, Crospovidone). Thirteen formulations were designed, using a two level of Superdisintegrants (minimum and maximum concentration) and employing two Superdisintegrants at a time by using the co-processed technique.
Results: No significant drug and excipients interaction was observed. The prepared tablets were evaluated by weight variation, thickness, hardness, friability, drug content uniformity, disintegration time, wetting time, in-vitro dissolution studies. A formulation containing 6mg of natural and synthetic Superdisintegrants was offered the relatively rapid release of montelukast sodium when compared with other concentrations employed in this investigation.
Conclusion: Montelukast sodium formulation were prepared by Crospovidone and ispaghula combination of Superdisintegrants were releases 98.91% drug in 30 min.
The concept of formulating Orodispersible tablets containing Levocetirizine hydrochloride offers a suitable, practical approach to achieve fast release of the drug. Absorption of these tablets takes place direct into the systemic circulation which avoids the hepatic first pass metabolism of Levocetirizine hydrochloride which ultimately results in the improvement in the bioavailability.In the present study ODT tablets of Levocetirizine HCl were prepared by using different super disintegrants like cross povidone, starch 1500, MCC 102. Nine formulations were designed, using higher and lower level of super disintegrants and employing two and three super disintegrants at a time. In the FTIR studies, it was concluded that there was no interaction between drug and super disintegrants used in formulation. Formulation LF9 which was consisted of 16.25 mg of Levocetirizine ionex complex, 7 mg of MCC 102, 4 mg of polyplasdone XL 10 and 67.88 mg of mannitol SD 100 showed better taste masking property with immediate disintegration and drug release.
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