Objective. To analyze the results of treatment of disseminated (polysegmental and multilevel) forms of hematogenous vertebral osteomyelitis (HVO) as compared with those of monosegmental and monovertebral lesions.Material and Methods. A retrospective analysis of a monocenter cohort of 266 patients with hematogenous osteomyelitis of the spine for 2006 to 2019 was carried out. Patients were divided into two groups: Group A (polysegmental and multilevel lesions) included 33 (12.4 %) patients and Group B (monosegmental and monovertebral lesions) – 233 (87.6 %) patients. The main examination methods were: clinical, radiological (standardized roentgenography, CT), MRI, microbiological, histological and statistical ones.Results. Comparison revealed that involvement of the cervical (p < 0.001) and thoracic (p = 0.014) spine was more typical for polysegmental and multilevel lesions. There was a tendency to the predominance of type A lesions according to the Pola classification in patients with local forms (p = 0.078) and to the increase in type C lesions in polysegmental and multilevel processes (p = 0.035). The number of neurological complications was higher in polysegmental and multilevel lesions (p = 0.003). There were no significant differences in the treatment results, the number of relapses and mortality rate between the compared groups.Conclusion. Lesions of the cervical and thoracic spine and the presence of a neurological deterioration are typical for multilevel and polysegmental HVO. The formation of a multilevel lesion in different regions of the spine with a gap of 2–4 weeks or more requires a separate implementation of the diagnostic algorithm, defining of classification criteria and differentiated treatment tactics for each focus.
Objective. Basing on experiment biomechanical and clinical studies to determine the optimal method of surgery in patients with vertebral lower thoracic and lumbar fractures using porous NiTi implants. Material and Methods. A method of modeling of comminuted vertebral fractures has been developed. The outcomes after anterior interbody fusion with both porous NiTi implants alone and in combination with pedicle screw fixation and on-bone screw – rod osteosynthesis for comminuted vertebral fractures in thoracic and lumbar spine were analyzed in 61 patients. An antimigration technique for implant stabilization was developed and successfully used in 5 patients with comminuted vertebral fractures predominantly in the lower lumbar spine. Patients of this group underwent stabilometry and X-ray tomography for objective appraisal of treatment results. Results. Results of the experimental studies demonstrated that anterior mono- and bisegmental spinal fusion with onbone screw – rod or transpedicular osteosynthesis provides stable fixation, but firmer fixation is achieved by its combination with anterior spinal fusion. Most patients (87.9 %) have good results after anterior interbody fusion with porous NiTi implants. Conclusion. Combination of anterior interbody fusion with porous NiTi implants and on-bone screw – rod osteosynthesis is advisable for unstable fractures and also for early active rehabilitation of patients without external immobilization. Anterior interbody fusion with titanium antimigration screw is advisable for comminuted vertebral fractures predominantly in lower lumbar spine.
Introduction: treatment of vertebral osteomyelitis is accompanied by various problems associated with the multidisciplinary nature of disease. The use of tactical classifications is absolutely essential. It is advisable to evaluate the results and effectiveness of treatment methods in accordance with the classification type of lesions. Purpose: to analyze outcomes of vertebral osteomyelitis treatment depending on lesions typesand treatment methods, according to E. Pola, 2017 classification. Materials and methods: results of treatment 266 patients with vertebral osteomyelitis, who were treated in 2006-2019, were analyzed. Type A lesions accounted for 24.1% (n=64), B - 47.0% (n=125), C" - 26.3% (n=70),vertebral processes lesions- 2.6% (n=7). Neurological deficit was in 53 cases. Conservative treatment, debridement, instrumentation, 3600 fusion were used. The evaluation of the results was carried out for more than a year after discharge. Results: conservative treatment of type A lesions led to recovery - 97.4% of cases compared with 3600 fusion (p=0.002) and relapses (p=0.034), mortality (p=0.001) are more common after reconstructive surgery. With lesions type B, the mortality after debridement was the highest - 15.8% (p=0.022). Analysis of type C lesions did not reveal significant differences between treatments methods. Mortality with sepsis was 17.4%, in its absence - 4.9% (p=0.039), relapses - 21.7% vs. 7.8% (p=0.043), recovery 56,6% vs. 83.5% (p=0.004), respectively. Differences in the long-term period for ODI, NDI, SF-36 were not revealed. Overall survival was 84.4%, long-term - 90.4% with a significant increase in conservative treatment compared with reconstructive surgery (p=0.045). Conclusion: conservative treatment and extrafocal stabilization show maximum efficiency with minimal destruction and uncomplicated lesions (type A), while reconstructive surgery leads to an increase in the number of relapses and mortality. Debridement in the septic course of lesions B leads to an increase in hospital mortality. For C lesions, there were no significant differences in the results of using the treatment methods.
Objective. To perform validation study of the E. Pola classification (2017) and to assess expert consensus on the diagnosis and treatment of infectious lesions of the spine in the national professional community.Material and Methods. A clinical and radiological database on 15 cases of infectious spondylitis, as well as the information about original article by Pola and a Russian translation of the classification and tactical tables from this article, were distributed to 408 orthopedic traumatologists, neurosurgeons and radiologists who have experience in treating patients with spinal pathology and whose data are available in the registers of the relevant professional associations of the Russian Federation. The coincidence/difference in the responses concerning the definition of lesion types and the choice of treatment tactics, as well as proposals for the use of classification were assessed.Results. Answers were obtained from 37 respondents from 11 regions of the Russian Federation. The general interobserver agreement index (Fleiss kappa) for all types of spondylodiscitis was 0.388 (95 % CI 0.374–0.402), including for lesion types: type A – 0.480 (95 % CI 0.460–0.499, type B – 0.300 (95 % CI 0.281–0.320), and type C – 0.399 (95 % CI 0.380–0.419). Agreement levels were higher among radiologists (type A – 0.486, type B – 0.484, and type C – 0.477), orthopedic traumatologists (type A – 0.474, type B – 0.380, and type C – 0.479), and specialists with clinical experience less than 10 years (type A – 0.550, type B – 0.318, and type C – 0.437). The pooled data for all 12 lesion subtypes showed general poor agreement (k = 0.247, CI 0.240–0.253), satisfactory level was found for B3.2 type (k = 0.561, CI 0.542–0.581), good agreement (k > 0.61) was achieved between orthopedic traumatologists for type B3.2 and between radiologists for B3.1 and B3.2 lesion types. Respondents refused to use basic treatment options for type A in 15.1 %, type B in 7.5 % and type C in 3.2 % of answers, while indicating the need for interventions through anterior approach in 24.7 %, 43.0 % and 46.2 %, respectively. Limitations of the classification use depending on the localization and etiology of spondylitis were noted. Authors recommended taking into account the presence of systemic inflammatory response syndrome, mandatory CT scanning, clarification of spinal instability criteria, and the addition of anterior surgical interventions to the treatment algorithm.Conclusion. The Pola classification of spondylodiscitis is currently considered the most successful for tactical algorithms and implementation in broad clinical practice for spondylodiscitis. However, at the stages of its clinical application, there is an unsatisfactory interobserver expert consensus on the types of lesions, and there are limitations related to the etiology, localization and severity of the disease. A modified classification taking into account the identified limitations and including anterior procedures in the tactical options is advisable.
Objective. To analyze lethal outcomes in patients with hematogenous vertebral osteomyelitis.Material and Methods. Study design: retrospective analysis of medical records. A total of 209 medical records of inpatients who underwent treatment for hematogenous vertebral osteomyelitis in 2006–2017 were analyzed. Out of them 68 patients (32.5 %) were treated conservatively, and 141 (67.5 %) – surgically. The risk factors for lethal outcomes were studied for various methods of treatment, and a statistical analysis was performed.Results. Hospital mortality (n = 9) was 4.3 %. In patients who died in hospital, average time for diagnosis making was 4 times less (p = 0.092). The main factors affecting mortality were diabetes mellitus (p = 0.033), type C lesion according to the Pola classification (p = 0.014) and age over 70 years (p = 0.006). To assess the relationship between hospital mortality and the revealed differences between the groups, a regression analysis was performed, which showed that factors associated with mortality were Pola type C.4 lesions (OR 9.73; 95 % CI 1.75–54.20), diabetes mellitus (OR 5.86; 95 % CI 1.14–30.15) and age over 70 years (OR 12.58; 95 % CI 2.50–63.34). The combination of these factors increased the likelihood of hospital mortality (p = 0.001). Sensitivity (77.8 %) and specificity (84.2 %) were calculated using the ROC curve. In the group with mortality, the comorbidity index (CCI) was significantly higher (≥4) than in the group without mortality (p = 0.002). With a CCI of 4 or more, the probability of hospital death increases significantly (OR 10.23; 95 % CI 2.06–50.82), p = 0.005. Long-term mortality was 4.3 % (n = 9), in 77.8 % of cases the cause was acute cardiovascular pathology, and no recurrence of vertebral osteomyelitis was detected.Conclusion. Hospital mortality was 4.3 %, and there was no mortality among patients treated conservatively. The main risk factors were diabetes mellitus, type C lesion according to Pola and age over 70 years. There was a significant mutual burdening of these factors (p = 0.001). With CCI ≥4, the probability of death is higher (p = 0.005).
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