Suicide is deliberate self-damage, often with a lethal outcome. The causes of suicidal behavior are multiple, complex, and largely unclear. Despite numerous studies on the social, biological, psychological, and psychiatric causes of suicide, as well as its gender, agerelated, and temporal characteristics [2][3][4][5], specific causes of suicide remain unknown. Suicide rates are increasing every year in connection with intense population aging and may become one of the leading causes of mortality in socially prosperous countries. However, suicides are distributed nonuniformly over the world. For example, suicides are considerably more frequent in Europe than in South America. This indicates that the etiology and pathogenesis of suicide behavior are unclear and require further studying.The mechanisms of individual predisposition to various diseases has become an urgent problem now, when the human genome is being deciphered [1,[6][7][8][11][12][13]. In the early 1980s, Academician L.A. Piruzyan enunciated the concept of personal "metabolic passport" for individualizing the prevention and chemotherapy of various diseases and decreasing side effects of drugs [6,7].The so-called "environmental" genes, i.e., the genes encoding xenobiotic detoxification enzymes, play an important role in the human metabolic passport. These are cytochrome P-450, NAT1, NAT2, GSTM1, and other enzymes whose forms largely vary due to genetic polymorphisms. The enzyme N-acetyl transferase (NAT2) belongs to the GNAT family; it is involved in the genetically determined biotransformation of exogenous (arylamines and heterocyclic compounds) and endogenous (lipids, hormones, neurotransmitters, immune factors, and inflammation factors) substrates and exhibits a bimodal distribution in human populations, dividing them into slow and fast N-acetylators according to the enzyme phenotype [11,12]. Neither of the N-acetylation phenotypes has been found to have a physiological advantage over the other. The numbers of fast and slow N-acetylators widely vary in different ethnic groups [6,7]. Twenty-eight polymorphic variants of the NAT2 gene have been found [12]. The distribution of NAT2 phenotypes has been demonstrated to be associated with geographical latitude [15], the frequency of the fast N-acetylation phenotypes increasing when moving to the equator.Arylalkyl N-acetyl transferase catalyzes the synthesis of melatonin from serotonin in the pineal gland. Melatonin regulates immunity; normalizes sleep; relieves depression; and possess antioxidant, sedative, antiproliferative, and protective properties. A decrease in melatonin synthesis in the pineal gland or disturbance of the rhythm of its secretion has been found in diabetes mellitus, depression, Alzheimer's diseases, Parkinson's disease, immunodeficiencies, and cancer [9,10,14]. The main function of the pineal gland is the regulation of circadian (daily) and circanual (seasonal) biorhythms, endocrine functions, metabolism, and adaptation to changing illumination. V. Pierpaoli considers the pineal gland ...
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