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The efficiency of cold steel rolling depends mainly on the quality of the metal-working coolant (MWC) and its cost. In this connection, it is actual to search for new compositions of lubricants and emulsions, which provide the lowest values of the friction coefficients in deformation zone and are obtained by waste recycling in other industries. In this study we have developed new compositions of the MWC on basis of mono- and diglycerides and their esters of boric acid synthesized from the wastes of sunflower oil production. The new compositions of MWC were tested in DSEA on laboratory rolling mill 100x100 with a roll diameter of 100 mm. The efficiency of new MWC during cold rolling of brass L63 samples was determined by factor of metal stretch forming λ. We found the new metal-working coolants to show the most efficiency under higher cobbing that provides the highest metal stretch forming. The composition with 30 % of mono- and diglycerides is the most effective because it provides the minimum coefficient of friction that leads to increase of factor of metal stretch forming. Thereby the metal-working coolants on basis of mono- and diglycerides obtained from the wastes of sunflower oil production can be recommended for use in strip rolling of copper-zinc alloys because of a low cost, availability and high efficiency.

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A method has been developed for the synthesis of granular polymeric materials with immobilized N-chloro-sulfonamide groups. Commercially available resin polymers widely applied for the preparation of ion exchangers have been used as polymer carriers. The elaborated technological conditions make it possible to modify these resins with a high conversion degree, without deteriorating the strength characteristics, and with the possibility of regulating the concentration of active chlorine over a wide range (up to 11 % w/w). The structure of the synthesized polymers was confirmed by IR spectroscopy data. To determine the concentration of functional groups, a special method of iodometric titration has been developed. The processes of emission of active chlorine from synthesized polymers into aqueous solutions have been studied. It has been shown that this process significantly depends on the composition of the solution: no release of active chlorine into distilled water is observed, and when using tap water, its concentration is reached 5–8 mg/dm3 and remains up to 30 days when the granules are in water. The processes of activation of active chlorine emission by compounds of amine nature have been studied, the corresponding kinetic curves of the dependence between change in the concentration of active chlorine in solution and the used activator are presented. It has been found that the nature of the used activator strongly affects, among other things, the stability of the obtained chlorine-active solutions. Taurine and sulfamic acid are found to be the optimal activators for obtaining stable solutions of active chlorine of high concentration. The composition of the N-chloro-taurin solution obtained in this way has been additionally analyzed by UV spectroscopy. Thus, the synthesized polymers make it possible to quickly in situ obtain high-purity solutions of active chlorine without the use of special electrochemical equipment. The polymers themselves are compact, stable, and can be repeatedly regenerated

Bleitetraacetat oxidiert die substituierten p‐Aminophenole (I)zu den p‐Benzochinon‐ monoiminen (II).

Depending on the reaction conditions N-arylsulfonyl-1,4-quinone imines with enamines led to the formation of the products of 1,4-addition, derivatives of benzo-and naphthofuran, indole, and benzindole.A multitude of publications describe the reactions of p-benzoquinone with enamines resulting in heterocyclic compounds: benzofuran (I) [1][2][3][4] or indole (II) [2, 3, 5-9] derivatives which are mostly biologically active substances [4,10,11]. The structure of the reaction products depends on the structure of initial compounds (it is the most strongly affected by the substituent at the nitrogen atom of the enamine) [2, 6, 8] and the conditions of the reaction [2,8,12].Several papers consider the reactions of N-arylsulfonyl-1,4-quinone imines with enamines, in particular, with imines of acetylacetone and ethyl 3-arylaminocrotonates [13][14][15][16]. The reaction of N-tosyl-1,4-benzoquinone imine with acetylacetone imine in methanol or acetic acid resulted in a heterocyclic derivative (I, X = TsNH, R 1 = COMe, R 2 = Me) [15,16], in acetone another structure was obtained (II, X = TsNH, R 1 = COMe, R 2 = Me, Y = 4-MeC 6 H 4 ) [16]. In reactions of N-tosyl-1,4-benzoquinone imine with esters of 3-arylaminocrotonic X O R 2 R 1 X N R 2 R 1 Y I II acid in chloroform or acetone only indole derivatives were obtained (II, X = TsNH, R 1 = COOEt, R 2 = Me, Y = 4-MeC 6 H 4 , Ph, 4-MeOC 6 H 4 ) [13, 14, 16], N-tosyl-1,4-naphthoquinone imine in acetone formed only the open-chain product of 1,4-addition [17]. The formation of indole derivatives is favored by the presence of an aryl substituent at the nitrogen atom of the enamine [13].Benzofuran derivatives were obtained at the hydrolysis of the addition products of the esters of 3-alkyl-and 3-arylaminocrotonic acids [18,19] to N-tosyl-1,4-benzoquinone monoimine. No research concerned the effect on the direction of this reaction of the substituents in the quinoid ring of the N-arylsulfonyl-1,4-quinone imines. It was formerly established that in the reactions of p-benzoquinone with enamines the substituents in the quinoid ring govern the direction of this reaction [4,6,7,9]. The goal of this study was the establishment of the effect of the reaction condition and the structure of Narylsulfonyl-1,4-quinone imines, in particular, of the position and the character of the substituent in the quinoid ring, on the direction of their reactions with the acetylacetone imine and the esters of 3-arylaminocrotonic acid .The reaction of N-arylsulfonyl-1,4-benzoquinone monoimines IIIа-IIIo with p-tolylaminopent-3-en-2-one (IVа) and esters of 3-arylaminocrotonic acid IVb, IVc was carried out in acetone, acetic acid, dichloroethane,

Розроблення, створення перев'язувальних матеріалів, що не мають токсичного впливу на організм, виявляють виражену антимікробну дію та не викликають резистентність хвороботворних мікроорганізмів, а також прискорюють процес епітелізації, -актуальна проблема сучасної медицини.Мета роботи -оцінювання токсикологічних характеристик перев'язувального матеріалу з вмістом активного хлору 6 % і 9 % при одноразовому нанесенні на шкіру, а також вивчення дії перев'язувального матеріалу на швидкість епітелізації неінфікованої ранової поверхні, визначення його антимікробної та ранозагоювальної активності in vivo на моделі рани, що інфікована S. аureus АТСС 6538.Матеріали та методи. Для оцінювання безпеки застосування та фармакологічної активності in vivo виконали експериментальне вивчення пов'язок з іммобілізованим полімерним N-хлорсульфонамідом натрію та N,N-дихлорсульфонамідом. Визначення токсикологічних характеристик досліджуваного перев'язувального матеріалу при одноразовому нанесенні на шкірні покриви виконали на лабораторних щурах і кроликах за загальноприйнятою методикою, вивчення ранозагоювальної дії -в тесті Л. Н. Попової, антимікробної активності in vivo -на моделі рани, що інфікована вшиванням шовкової нитки, просоченої добовою культурою S. аureus АТСС 6538.Результати. Фармакологічними дослідженнями гострої токсичності тест-зразків матеріалів із вмістом активного хлору 6 % і 9 % при одноразовому нанесенні на шкірні покриви щурів і кролів встановлено, що аплікації не призводили до випадків загибелі, а також змін у поведінці тварин, споживанні ними корму, води. Швидкість епітелізації неінфікованої поверхні рани за умов застосування пов'язок як з N-хлорсульфонамідом натрію, так і з N,N-дихлорсульфонамідом до завершення періоду спостереження (14 доба) вірогідно значущо збільшувалася в середньому в 1,5 раза порівняно з тваринами групи УДК: 541(183.12+64):615.1 ГУ «Днепропетровская медицинская академия МЗ Украины», г. Днипро, 2 ГВУЗ «Украинский государственный химико-технологический университет», г. Днипро A -концепция и дизайн исследования; B -сбор данных; C -анализ и интерпретация данных; D -написание статьи; E -редактирование статьи; F -окончательное утверждение статьи Разработка и создание перевязочных материалов, не оказывающих токсического действия на организм, проявляющих выраженное антимикробное действие и не вызывающих резистентность болезнетворных микроорганизмов, а также ускоряющих процесс эпителизации, -актуальная задача современной медицины.Цель работы -оценка токсикологических характеристик перевязочного материала с содержанием активного хлора 6 % и 9 % при одноразовом нанесении на кожные покровы, а также изучение действия перевязочного материала на скорость эпителизации неинфицированной раневой поверхности и определение его антимикробной и ранозаживляющей активности in vivo на модели раны, инфицированной S. аureus АТСС 6538.Материалы и методы. Для оценки безопасности применения и фармакологической активности in vivo проведено экспериментальное изучение повязок с иммобилизированным полимерным N-хлорсульфонами...

Virucidal properties of N-chlorosulfonamides immobilized on fibrous styrene-divinylbenzene copolymers have been studied. Corresponding materials with different functional group structures and chlorine content have been synthesized on FIBAN polymer carriers in the form of staple fibers and non-woven fabrics. The study has been conducted in general accordance with EN 14476 standard on poliovirus type-1 and adenovirus type-5. It has been found that all tested samples exhibit pronounced virucidal activity: regardless of the carrier polymer form, sodium N-chlorosulfonamides inactivated both viruses in less than 30 s, and N,N-dichlorosulfonamides—in 30–60 s. The main mechanism of action of these materials, obviously, consists in the emission of active chlorine from the functional group into the treated medium under the action of the amino groups of virus fragments and cell culture. Considering the previously described antimicrobial and reparative properties of such materials, as well as their satisfactory physical and mechanical properties, the synthesized polymers are promising for the creation of medical devices with increased resistance to microbial contamination, such as protective masks, filter elements, long-acting wound dressings, and others.