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Western blot analyses for total ␣1 and ␤2 adrenoreceptor abundance in IMA segments were not different between men and women. Assessment of subcutaneous microvascular responses of healthy females undergoing elective hernia repair were also more sensitive to U46619 and phenylephrine compared to men.Conclusion: This is the first documentation of a selective hypersensitivity to vasoconstrictors in females, with increased sensitivity in the arterial segments to both thromboxane and phenylephrine, and to the later in subcutaneous microvessels. This may predispose to myocardial ischaemia in women and contribute to the increased post-operative mortality.http://dx.

S S20Heart, Lung and Circulation CSANZ 2012 Abstracts 2012;21:S1-S142 9 expression and reduce nSmad3 count suggesting inhibition of downstream effects of TGFB receptor activation. The results support a rationale for the use of these agents in subjects with thoracic aortic aneurysm disease.http://dx. Introduction:Peripheral artery disease is an atherothrombotic disorder, however, microvascular spasm is also important and medical therapies to attenuate spasm are limited. The aim of this study was to identify: (1) whether the response to specific agonists was altered in the microvasculature of patients suffering with peripheral artery disease and (2) whether these responses were dependent on the activity state of endothelial nitric oxide synthase and/or myosin phosphatase.Methods: Microvessels from age matched healthy controls and patients suffering with peripheral artery disease (n = 15) were isolated from subcutaneous tissue and mounted on a wire myograph. The dosedependent responses to the thromboxane mimetic (U46619), endothelin-1, phenylephrine and serotonin was determined. The activation state of endothelial nitric oxide synthase and myosin phosphatase was quantified using ratiometric phosphorylation analysis of P[Ser1177]eNOS/eNOS and P[Thr855MYPT]/MYPT, respectively.Results and conclusions: Compared with control patients the microvessels from patients with peripheral artery disease had normal levels and activation states of endothelial nitric oxide synthase and myosin phosphatase (p > 0.05). Patients with peripheral artery disease had normal contractile responses to exogenously applied U46619 (p > 0.05) but showed a decreased sensitivity to endothelin-1 and phenylephrine (p < 0.05). However,

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