The structure of mappicine, a minor alkaloid isolated from Mdppia foetida Miers. has been established as ( I I a ) (7-(1 -hydroxypropyl)-8-methylindolizino[l.2-b]quinolin-9(11 H)-one) by partial synthesis from camptothecin Centre, Goregaon, Bombay 400 063, India (W.WE have previously reported the isolation of the antitumour alkaloid camptothecin (Ia) from Mappia foetida Miers (family; Olacaceae) . l s 2 A new alkaloid isolated from the plant was shown to be 9-methoxycamptothecin (Ib) by spectral studies. T.1.c. examination of the mother liquors of crystallisation of these alkaloids showed the presence of traces of more polar compounds with green or blue U.V. fluorescence. By repeated chromatography of this material over silica gel we have isolated 1 T. R. Govindachari and N. Viswanathan, Indian J . Chsm., 1972, 10, 463.one new alkaloid in very small yield. This has been named mappicine and we now report evidence leato structure (IIa) for the alkaloid.Mappicine, C1,Hl,N2O2 (M+ 306), has a U.V. spectrum closely resembling that of camptothecin (Ia). Its i.r. spectrum shows bands a t 3380, 3280 (OH), 1660, and 1590 cm-f (pyridone) but lacks the a-lactone peak at 1745 cm-1 which is present in camptothecin. Acetylation of mappicine gives a monoacetate. The n.m.r.
Für die aus den Wurzeln von Inula racemosa isolierten neuen Lactone Inunolid, Dihydroinunolid bzw. Neoalantolacton werden anhand spektroskopischer Untersuchungen sowie chemischer Reaktionen die Strukturen (I), (II) bzw. (III) ermittelt.
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