The dihydrofolate reductase (DHFR) domain of P. falciparum is one of the few well defined targets in malarial chemotherapy. The enzyme catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH) dependent reduction of dihydrofolate to tetrahydrofolate. Protein-ligand interactions were studied using DHFR protein 2BL9, extracted from PDB to evaluate the strength of affinity of various molecules towards ligand binding site and to study the extent of correlation between experimental values and computational dock scores. AutoDock runs resulted in binding energy scores from -7.14 to -10.72 kcal/mol. Among the five inhibitors (Bioorganic and Medicinal Chemistry Letters 15 2005 531-533) selected for docking studies, an excellent correlation was observed in all cases, for instance, experimentally reported most active molecule 2a (MIC: 1µg/ml) showed a high dock score (-10.72 kcal/mol) than the remaining inhibitors. Therefore, molecular docking using AutoDock suggests the importance of evaluating the prediction accuracy of various molecules as evidenced by a correlation coefficient of 0.961 between experimental activities and AutoDock binding energies.

Assigning functions to proteins of unknown function is of considerable interest to the proteomic researchers as the genes encoding them are conserved over various species. Here, we describe HypoDB, a database of hypothetical genes and proteins in six eukaryotes. The database was collected and organized based on the number of entries in each chromosome with few annotations. Hypothetical protein database contains information related to gene and protein sequences, chromosome number and location, secondary and tertiary structure related data.AvailabilityThe database is available for free at http://www.trimslabs.com/database/hypodb/index.html

Wormian bones are accessory bones are not normally present in skull. They may or may not be associated with clinical abnormalities. In the present study a significant number of wormian bones were identified at the Department of Anatomy, Andhra Medical College, Visakhapatnam. Their incidence with other population were done in the present study.

Renal artery variations are more important for surgeons and clinicians. As these variations alter and influence the surgical procedures including intervention methods. These variations are associated with physiological and embryological changes which will alter the medical treatment. The present work is conducted in the department of anatomy, Andhra medical college, Visakhapatnam for 50 cadavers for a period of 3 years. In one case 3 additional renal arteries arising from abdominal aorta one on right, two on left side were found.

Parkinson's disease (PD) is an age-related neurodegenerative disorder affecting many people in the world. Several gene mutations have shed light on the mechanisms of pathogenesis of PD. The parkinsonian syndrome is associated with several other degenerative and non-degenerative diseases. Genes linked to PD are synuclein, Parkinson's disease autosomal recessive, juvenile 2, Parkinson's disease autosomal recessive, early onset 7, PTEN-induced putative kinase 1 and leucinerich repeat kinase 2. The initial symptomatic therapy and adjuvant therapy in later PD are also discussed.