The reaction of 1,1‐dibromo‐2,2‐bis(chloromethyl)cyclopropane (2) with methyllithium in ether led to a solution of [1.1.1]‐propellane (1) in a yield of 70%. 1 could also be prepared free of solvent by reaction of 2 with lithium powder in triglyme/n‐decane at 73°C.
GAL seems to be ineffective when used in relapse prevention of detoxified alcoholics. It is possible that alcohol needs to be "on board" for GAL to be beneficial. This could explain why our post hoc analysis showed that GAL possibly reduces the alcohol consumption of relapsers. If confirmed, GAL could play a role in the reduction of harmful alcohol use and at-risk consumption.
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