Signal transducer and activator of transcription 3 (STAT3) play key roles in the intracellular signaling pathways of the interleukin (IL)-6 family of cytokines, which exhibit a diverse set of cellular responses, including cell proliferation and differentiation. Dysregulated IL-6/ STAT3 signaling is involved in the pathogenesis of several diseases, for example autoimmune diseases and tumors. Type I interferon (IFN) induces the expression of proapoptotic genes and has been used in the clinical treatment of several tumors. In the present study, we found that type I IFN suppressed IL-6/STAT3-mediated transcription and gene expression. Furthermore, a type I IFN-induced protein, Daxx, also suppressed STAT3-mediated transcriptional activation, while overexpression of Daxx inhibited IL-6/STAT3-mediated gene expression. Importantly, small-interfering RNA-mediated reduction of Daxx expression enhanced IL-6/leukemia inhibitory factor (LIF)-induced STAT3-dependent transcription. Co-immunoprecipitation studies revealed a physical interaction between Daxx and STAT3 in transiently transfected 293T cells. We further found that Daxx and STAT3 were co-localized in the nucleus. These results indicate that Daxx may serve as a transcriptional regulator of type I IFN-mediated suppression of the IL-6/ STAT3 signaling pathway.
1995 dielectric properties, magnetic properties dielectric properties, magnetic properties D 9000
-012Effect of Interstitial Hydrogen and Nitrogen on Magnetic and Structural Properties of R2T17 (R: Y, Ce and Sm; T: Fe, Co and Ni). -The title effects are investigated by XRD and magnetic measurements of R2T17 hydrides and nitrides. The saturation moment, Ms of Y2Fe17Ny compounds increases from 34.0 µB at y = 0 to 39.7 µB for y = 3.1 while that of the hydrides Y2Fe17Hx decreases from 34.0 to 32.8 µB for x = 2.9 and recovers to 34.4 µB for x = 4.6. The Curie temp., Tc, increases from 300 to 701 K upon nitrogenation and to 481 K for an H uptake of x = 2.9. For Y2Co17 hydrogenation and nitrogenation lead to a significant decrease of both Ms and Tc and Y2Ni17 loses its ferromagnetism upon hydrogenation and becomes paramagnetic even at 4.2 K. Conversion to ferromagnetism upon nitrogenation and hydrogenation of Ce2Fe17 is attributed to the decrease in the hybridization between Ce 4f and Fe 3d electron states by lattice expansion. -(FUJII, H.; AKAYAMA, M.; NAKAO, K.; TATAMI, K.; J. Alloys Compd. 219 (1995) 10-15; Fac. Integr. Arts Sci., Univ., Higashi-Hiroshima 724, Japan; EN)
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