To investigate the pathophysiology of hypertension in patients receiving recombinant human erythropoietin (rHuEpo) we studied its effects on the renin-aldosterone axis of chronic haemodialysis (HD) patients not receiving antihypertensive drugs. Nine severely anaemic normotensive HD patients received rHuEpo 50 U/kg bodyweight, thrice weekly after each HD. The dose was increased by 25 U/kg bodyweight every 4 weeks to a maximum of 100 U/kg or until an increase of Hb or Hct of 2 g/dl or 7% was achieved. Blood samples were taken after 30 min supine rest and while seated 10 min later after gentle ambulation. Results expressed as mean +/- SEM: therapy in normotensive HD patients by a negative feedback loop, before the development of hypertension.
Medical Research Societythalamic l e v e l , w i t h a consequent r e d u c t i o n i n t
h e increments o f plasma c o r t i s o l and c o r t i c os t e r o n e a f t e r a t r o p i n e a d m i n i s t r a t i o n .Aldos t e r o n e r e l e a s e a f t e r hypoglycaemia o c c u r s independently of a d r e n e r q i c d e n e r v a t i o n and c h o l i n e r g i c blockade and t h e r e f o r e probably r e s u l t s from a c t i v a t i o n o f t h e r e n i n -a q i o t e n s i n system r a t h e r t h a n from ACTH s t i m u l a t i o n .
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