Adaptation of uteroplacental arteries in patients with early-onset preeclampsia combined with IUGR is compromised due to insufficient invasion of extravillous trophoblast cells (EVT) into the spiral artery wall. The underlying molecular mechanisms are widely unknown. We investigated expression and possible mechanisms of regulation of different matrix-metalloproteases (MMPs) by EVT in placental bed biopsies from patients with early onset preeclampsia combined with IUGR and healthy pregnant women. Expression of MMP-3 and MMP-7 by EVT was markedly reduced in preeclamptic patients, especially close to spiral arteries. In contrast to healthy pregnancies these cells strongly expressed the receptor for leukemia inhibitory factor (LIF). LIF is known to suppress MMP-expression and is produced by uterine natural killer (uNK) cells which we found to be present in higher concentrations in the placental bed of preeclamptic patients, and accumulating aside the spiral arteries. We speculate that in preeclampsia a maternal immune cell network accumulating and interfering in the placental bed leads to an altered cytokine environment, resulting in disturbed trophoblast cell function such as impaired MMP expression and reduced invasiveness.
The findings suggest that both decidual LGLs and a subset of decidual T cells are activated and possibly play a role in the control of trophoblast growth and placental development.
A new formula for the prenatal estimation of the weight of extremely preterm fetuses was derived using ultrasound measurements and birth weights of 73 premature infants delivered before 30 completed weeks of pregnancy and weighing between 400 and 1,680 g at birth. The actual birth weight lay within ± 15% of the estimated weight calculated with this formula in 92% of the cases. Preliminary testing of the reliability of the formula was performed on a further test group of 19 nonselected cases. The formula developed in this study offers a reliable and simple method of prenatal estimation of fetal weight between 23 and 30 weeks of gestation.
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