The syntheres of two analogues of lowdensity lipoprotein (LDL) labelled with 123i Rabbit LDL was employed or l3'I was optimized for radbpharmaceutlcal application.due to its uoefulness in pre-cliniml experimentation, although the parameters which were optlmlzed also pertain to human LDL. LDL was iodinated directly with exchange-labelled rpl]lCl to produce Injectable Val]LDL in 40% radiochemical yield within 30 min. A derlvatized version of LDL, ral]TC-LDL, radiochemical yield within 75 min by radioiodination of tyraminecellobiose (TC) via h . c & oxidation of 9followed by cross-linking to LDL using cyanuric chloride. Quality control tests Indicated that both radloiodinated LDL and TC-LDL were very similar in character to the native LDL molecule.was produced In about 30%
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