We constructed an 11-arm, walk-through, human radial-arm maze (HRAM) as a translational instrument to compare existing methodology in the areas of rodent and human learning and memory research. The HRAM, utilized here, serves as an intermediary test between the classic rat radial-arm maze (RAM) and standard human neuropsychological and cognitive tests. We show that the HRAM is a useful instrument to examine working memory ability, explore the relationships between rodent and human memory and cognition models, and evaluate factors that contribute to human navigational ability. One-hundred-and-fifty-seven participants were tested on the HRAM, and scores were compared to performance on a standard cognitive battery focused on episodic memory, working memory capacity, and visuospatial ability. We found that errors on the HRAM increased as working memory demand became elevated, similar to the pattern typically seen in rodents, and that for this task, performance appears similar to Miller's classic description of a processing-inclusive human working memory capacity of 7 ± 2 items. Regression analysis revealed that measures of working memory capacity and visuospatial ability accounted for a large proportion of variance in HRAM scores, while measures of episodic memory and general intelligence did not serve as significant predictors of HRAM performance. We present the HRAM as a novel instrument for measuring navigational behavior in humans, as is traditionally done in basic science studies evaluating rodent learning and memory, thus providing a useful tool to help connect and translate between human and rodent models of cognitive functioning.
Free-recall tasks suggest human memory foraging may follow a heavy-tailed distribution, such as a Lévy flight, patch foraging, or area-restricted searchwalk procedures that are common in other activities of cognitive agents, such as food foraging in both animals and humans. To date, research merely equates memory foraging with hunting in the physical world based on similarities in statistical structure. The current work supports that memory foraging follows a heavy-tailed distribution by using categories with quantitative distances between each item: countries, which have physical distances, and animals, from which cognitive distances can be derived using a multidimensional scaling (MDS) procedure. Likewise, inter-item lag times follow a heavy-tailed distribution. The current work also demonstrates that inter-item distances and times are positively correlated, suggesting the organization of items in memory may be akin to the organization of a physical landscape. Finally, both studies show that participants' original, heavy-tailed lists of countries and animal names produce shorter overall distances traveled than random selection. Human memory foraging follows the same pattern as foraging in the natural worldperhaps because exposure to ecological settings informs our inner cognitive experienceleading to a processing and retrieval time benefit.
Yorùbá dùndún drumming is an oral tradition which allows for manipulation of gliding pitch contours in ways that correspond to the differentiation of the Yorùbá linguistic tone levels. This feature enables the drum to be employed as both a musical instrument and a speech surrogate. In this study, we examined four modes of the dùndún talking drum, compared them to vocal singing and talking in the Yorùbá language, and analyzed the extent of microstructural overlap between these categories, making this study one of the first to examine the vocal surrogacy of the drum in song. We compared the fundamental frequency, timing pattern, and intensity contour of syllables from the same sample phrase recorded in the various communicative forms and we correlated each vocalization style with each of the corresponding drumming modes. We analyzed 30 spoken and sung verbal utterances and their corresponding drum and song excerpts collected from three native Yorùbá speakers and three professional dùndún drummers in Nigeria. The findings confirm that the dùndún can very accurately mimic microstructural acoustic temporal, fundamental frequency, and intensity characteristics of Yorùbá vocalization when doing so directly, and that this acoustic match systematically decreases for the drumming modes in which more musical context is specified. Our findings acoustically verify the distinction between four drumming mode categories and confirm their acoustical match to corresponding verbal modes. Understanding how musical and speech aspects interconnect in the dùndún talking drum clarifies acoustical properties that overlap between vocal utterances (speech and song) and corresponding imitations on the drum and verifies the potential functionality of speech surrogacy communications systems.
INTRODUCTIONResting‐state functional magnetic resonance imaging (fMRI) graph theory may help detect subtle functional connectivity changes affecting memory prior to impairment.METHODSCognitively normal apolipoprotein E (APOE) ε4 carriers/noncarriers underwent longitudinal cognitive assessment and one‐time MRI. The relationship of left/right hippocampal connectivity and memory trajectory were compared between carriers/noncarriers.RESULTSSteepness of verbal memory decline correlated with decreased connectivity in the left hippocampus, only among APOE ε4 carriers. Right hippocampal metrics were not correlated with memory and there were no significant correlations in the noncarriers. Verbal memory decline correlated with left hippocampal volume loss for both carriers and noncarriers, with no other significant volumetric findings.DISCUSSIONFindings support early hippocampal dysfunction in intact carriers, the AD disconnection hypothesis, and left hippocampal dysfunction earlier than the right. Combining lateralized graph theoretical metrics with a sensitive measure of memory trajectory allowed for detection of early‐stage changes in APOE ε4 carriers before symptoms of mild cognitive impairment are present.Highlights Graph theory connectivity detects preclinical hippocampal changes in APOE ε4 carriers. The AD disconnection hypothesis was supported in unimpaired APOE ε4 carriers. Hippocampal dysfunction starts asymmetrically on the left.
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