A 62-year-old man was admitted to our Neurology Unit due to consciousness disturbance. Laboratory data showed marked hypercalcemia and azotemia. Serum parathyroid hormonerelated protein (PTHrP) level was extremely high. We performed intensive hemodialysis for renal failure, but his condition deteriorated rapidly. On day 10, he died of multiple organ failure. The autopsy revealed gastric undifferentiated adenocarcinoma with systemic dissemination. Immunohistological study showed positive PTHrP staining in carcinoid-like parts of the tumor. This is the first reported case of malignant hypercalcemia due to PTHrP-producing carcinoid or endocrine cell carcinomaof the stomach.
Extragenital choriocarcinoma in the male is known to occur in retroperi‐toneum, mediastinum and pineal body in a high proportion, and there have been no certain reports of lung origin. We studied two cases of choriocarcinoma arising from the lung in the male by histological, electronmicros‐coplcal, immunofluorescent, and immunoenzyme methods. Histologically, characteristic changes of choriocarcinoma, composed of irregular complex of cytotrophoblasts and syncytiotrophoblasts with massive necrosis and hemorrhage were demonstarated. These two cell patterns, characteristic of choriocarcinoma, were also demonstrated electronmicroscopically and differed from giant cell carcinoma of the lung. By immunofluorescent and Immunoenzyme methods, anti‐HCG reactive particles were seen in the cytoplasm mainly of syncytiotrophoblasts and proved HGG production function of the tumor.
Seven cases of senile dementia of Alzheimer type (SDAT) with unusual clinico-pathological findings are reported. The patients showed neuronal loss in laminar pattern, with gliosis exclusively confined to the CA1 of the hippocampus, the area of the hippocampal gyrus (entorhinal cortex) and medial occipitotemporal cortex. This change was more pronounced in the oral region. The subcortical white matter showed more pronounced fibrillary gliosis than loss of myelin. Both Alzheimer's neurofibrillary tangles and senile plaques were less marked than those usually seen in SDAT. The mental disturbance started after the age of 65 in all patients. The main clinical feature was marked character change in addition to disturbance of cognitive function. Cranial computed tomography showed marked dilatation of the oral portion of the inferior horn of the lateral ventricle in the early stage. It was apparent that although the cases in this group could be incorporated within in the spectrum of SDAT, they could also be considered to represent a variant of SDAT. This group could contribute to an understanding of the clinico-pathological spectrum of SDAT as well as indicating ways of managing such patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.