Summary. The most formidable early postoperative complications of Lewis esophagogastroplasty (EGP) is the failure of esophagogastroanastomosis (EGA), and in the late period — stricture of EGA, in some patients there are functional disorders. The aim of the study. Assess the treatment of complications of EGP using minimally invasive methods. Materials and methods: The results of 150 operations for cancer of the middle and upper thoracic esophagus with the imposition of high EGA were analyzed (65 used cervical EGP). X-ray endoscopic techniques are used to treat patients with complications. The functional results of EGP using esophageal manometry and pHZ monitoring were also evaluated. Results and discussion. When applying EGA on the neck was significantly higher incidence of failure of the anastomotic sutures, which was associated with impaired blood supply with increasing length of the graft. Surgical tactics in case of failure of the EGA on the neck was to open and drain the deep space of the neck, conducting a transnasal tube for feeding into the stomach — there were no fatalities. Surgical tactics in case of failure of intrapleural EGA, which took place in 4 cases, consisted of drainage of the empyema cavity and conducting a transnasal tube for nutrition in the initial parts of the small intestine under X-ray video surveillance. In the treatment of failure of intrathoracic anastomoses there was 1 fatal case. At strictures of EGA which took place at 24 patients, performed balloon dilatations under X-ray video control. In 2 patients with the phenomena of pylorospasm performed balloon dilatation of the pyloric pulp under X-ray video control. In general, patients who underwent EGP showed good and satisfactory functional results, but in some patients there were functional disorders that were transient in nature. Conclusions: The use of clinically developed methods of esophagogastroplasty can reduce the number of failures and strictures of anastomoses. At insufficiency and strictures of an esophagogastroanastomosis, and also at a hypertonia of pyloric pulp X-ray endoscopic methods are highly effective and low-traumatic.
Chronic pancreatitis is a recurrent progressive disease accompanied by fibrosis and fibrocystic degeneration of the pancreatic parenchyma. There are remained the unexplored issues of progression of fibrosis in the pancreas parenchyma, which lead to a rapid enlargement of the head, the development of complications that require a resection surgery. To develop a differentiated approach to the choice of surgical treatments and indications for pancreatoduodenal resection in complicated forms of chronic pancreatitis, a study was performed in 137 patients underwent resection and drainage surgery. Pancreatoduodenal resection was accomplished in 12 patients. Instrumental research methods were used: multidetector (64−slice) computed tomography with 3D reconstruction, magnetic resonance imaging, magnetic resonance cholangiopancreatography, endoscopic retrograde cholangiopancreatography. Two clinical examples are given. Indications for pancreatoduodenal resection in patients with chronic pancreatitis were expressed fibro−inflammatory process in the area of the pancreas head, suspected development of oncological pathology. Progressive fibrotic changes in the pancreas parenchyma, mainly in the head, occurring in some patients, associated with stellate cell activation and fibrogenesis, they lead to the development of biliary and portal hypertension, stimulation of oncogenesis. It is concluded that with the progression of fibro−inflammatory process in the pancreas head with the development of complications (pancreatic, biliary and portal hypertension), as well as in case of impossibility to exclude the tumor, the surgery of choice is pancreatoduodenal resection. The presence of severe fibrosis in the pancreas parenchyma reduces the risk of developing pancreatic fistula when performing pancreatoduodenal resection. Key words: complicated forms of chronic pancreatitis, pancreatoduodenal resection, fibro−inflammatory process, pancreatic fistula
The aim of this study was to evaluate changes in the level of erythrocyte metabolism under conditions of hypoxia in patients with traumatic disease in polytrauma depending on the components of intensive care (IC). Materials and methods. A prospective study was carried out in 88 patients suffering from polytrauma in the period from 2015 to 2017. All the patients were divided into 2 groups, comparable by severity of trauma and condition. A special feature of the examined patients was the staged surgical correction in all cases according to the Damage Control concept. Patients from the Control group received an intensive care according to the standard local clinical protocol in polytrauma. Patients randomized to the FDP group were treated with infusion of D-fructose-1,6-diphosphate sodium hydrate in addition to the standard care. Hemodynamic parameters and cellular metabolism indicators were monitored: on admission to the operating room, after 24 hours, on day 3, 5 and 14. Results. The signs of hypovolemia were equally severe in both groups on admission to the operating room. The FDP group demonstrated more rapid stabilization of hemodynamics and improved myocardial contractility at the 3rd day of IC. The monitoring of acid-base balance and carbohydrate metabolism showed the presence of compensated metabolic acidosis and energy deficiency. High indexes of lactate/pyruvate indicated a sharp imbalance in the ratio of aerobic/anaerobic metabolic processes. The analysis of ATP dynamics displayed impaired mitochondrial ATP production and inhibition of the glycolytic pathway of energy release. Conclusions. Complementary systemic inflammatory response with the elevation of lactate level by the 5th day occurred in patients with traumatic disease who underwent staged surgical correction. Optimization of intensive care resulted in a faster restoration of the balance between aerobic and anaerobic metabolic processes, an increase in the level of ATP and the rate of 2,3-DPG production in erythrocytes contributing to adequate oxygen supply to the tissues, supporting cellular respiration and preventing the development of oxidative tissue damage, as well as helped to maintain compensatory mechanisms and reduce cellular hypoxia ensuring adequate metabolism of vital organs.
Summary. Aim. To study the characteristics of gastroesophageal reflux using pH-impedance monitoring. Materials and methods. pH-impedance monitoring was carried out in 38 patients with GERD symptoms without endoscopic signs and 22 patients with endoscopic signs of reflux esophagitis and reflux gastritis. Results. All studied parameters confirmed the physiological nature of GER in 38 patients of group I and 9 patients of group II; the presence of pathological GER and impaired gastroesophageal antireflux barrier function in 13 patients of group II. Conclusions. The conducted pH-impedance monitoring made it possible to determine not only acidic GER and superrefluxes, but also weakly acidic and weakly alkaline ones, most accurately obtain quantitative and qualitative characteristics of GER, as well as establish a violation of the chemical and volumetric clearance of the esophagus. The data obtained can be used when choosing the method of antireflux surgery in patients with GERD.
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