The addition of chlorine to benzene results in the formation of a mixture of isomeric forms of 1,2,3,4,5,6-hexachlorocyclohexane, as follows: CeHe + 3C12 ->• CgHeCle. The most recent article on this subject (11) describes four isomers, the alpha, beta, gamma, and delta, of a possible sixteen isomers that are proposed. The present paper is concerned with the isolation of the epsilon isomer from the chlorination process product, the physical and chemical properties of the new isomer, infrared absorption spectra,x-ray powder diffraction patterns, and solubility data. WHEN the known isomers of hexachlorocyclohexane• were being separated, it was noted that an impurity was present in some of the fractions. This impurity was first found in the infrared absorption curves and was called impurity A. A sample in which this impurity was especially strong was analyzed, and
Multiple regression analysis was used to separate the contribution that the thiomethyl and sulfonylmethyl group as well as the P=0 and P=S groups made on the insecticidal activity in a series of organophosphates. The analysis indicated the possibility that thiomethyl and the P=S group had to undergo transformation to a more reactive species. The biological activity of the series of phosphates rep-resented by the sulfonylmethyl and the P=0 correlated quite well with the partition coefficient and the rate of alkaline hydrolysis. One surprising observation is the indication that the thiomethyl phosphorothioate which is most stable to nucleophilic attack should be the most active as an insecticide.
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