Forty-nine patients were treated with either 3 x 75 MBq 89Sr or saline as placebo. Analysis of results 1 to 3 years after therapy revealed the ineffectiveness of 89Sr to relieve pain from metastases. Unexpectedly, a higher survival rate was found after Sr application (46% vs 4% after 2 years). Covariate analysis underlines the effect of 89Sr therapy on life expectation.
In 14 patients with chronic renal failure and without obvious signs of congestive heart failure, cardiac function was analyzed immediately before and after hemodialysis through radiocardiography, phonocardiography and X-ray examination. Plasma creatinine, urea nitrogen and body weight were reduced by hemodialysis, whereas electrolyte levels remained relatively constant. Cardiac output, stroke volume, arterial pressures, and left ventricular work were generally elevated in these patients before hemodialysis, and were not affected by the procedure. Changes in heart volume, mean ejection rate, Lüthy’s index, and gallop sounds suggested an improvement of heart function after hemodialysis. In the absence of typical heart failure, an excessive water load may deteriorate cardiac performance in these patients by cardiac enlargement concomitant with hypertension. Thus overhydration should be avoided and cardiac function assessed by radiologic measurement of heart size and phonocardiography.
Following a firm diagnostic and therapeutic schedule for patients with prostatic carcinoma. 89Strontium therapy was introduced for multiple metastases. Positive skeletal scintigraphy with 99mTc-EHDP induced check for affinity to Sr using 85Sr scintigraphy. Of 80 patients, multiple metastases were found in 26. Therapy with 1 mCi of 89Sr-chloride was started in 20 cases. In 8 patients, relief from severe pain appeared shortly afterward, and a further 8 it was possible to prevent the development of pain. Moderate success in 3 cases and a failure to provide relief in 1 were observed.
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