Objective: We aimed to examine the general health and intestinal physiology of young and old non-human primates with comparable life histories and dietary environments. Design: Vervet monkeys (Chlorcebus aethiops sabaeus) in stable and comparable social and nutritional environments were selected for evaluation. Health phenotype, circulating cytokines and biomarkers of microbial translocation (MT) were measured (n=26–44). Subsets of monkeys additionally had their intestinal motility, intestinal permeability, and fecal microbiomes characterized. These outcomes document age-related intestinal changes present in the absence of nutritional stressors, which are all known to affect gastrointestinal motility, microbiome, and MT. Results: We found that old monkeys have greater systemic inflammation and poor intestinal barrier function as compared to young monkeys. Old monkeys have dramatically reduced intestinal motility, and all changes in motility and MT are present without large differences in fecal microbiomes. Conclusion: We conclude that deteriorating intestinal function is a feature of normal aging and could represent the source of inflammatory burden yet to be explained by disease or diet in normal aging human primate populations. Intestinal changes were seen independent of dietary influences and aging within a consistent environment appears to avoid major microbiome shifts. Our data suggests interventions to promote intestinal motility and mucosal barrier function have the potential to support better health with aging.

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Zusammenfassung Unter 49 autopsierten Paracoccidioides‐Mykosen fanden sich 4 Fälle hämatogen ent‐standener fungischer Aortitis. Nachfolgende Thrombose führte in 3 Fällen zu schweren Zirkulationsstörungen der Beine, in einem zur Nekrose des Darms und der Milz durch Embolien der entsprechenden Arterien. Fungische Absiedelungen innerhalb der Aorten‐wand sind bei Paracoccidioides‐Mykose offenbar nicht so selten, bisher allerdings nur in Venezuela beobachtet. Ihre wahre Natur kann auch autoptisch leicht verkannt werden. Hinweise für eine klinische Diagnose bieten neben entsprechenden Lungenbefunden zeit‐und örtlich auf arterielle Versorgungsareale begrenzte Geschwürsaussaaten der Haut. Sie erklären sich durch Embolisierung infizierten Thrombusmaterials, das sich über den spezi‐fischen Wandschäden abscheidet. Summary Among 49 cases of necropsiated paracoccidioidomycosis, 4 cases of paracoccidioido‐mycotic aortitis of hematogenous origen were found. Associated aortic thrombosis in 3 cases caused severe circulatory disturbances in the legs and in 1 case in spleen and intestine. Apparently hematogenous fungic aortic colonization is not so rare; but to day observed only in Venezuela. Paracoccidioidomycotic aortitis can be confused with arterio‐sclerotic manifestations. Lesions in lungs, adrenal glands and dermic ulcers in limitated territories of the body, especially in the legs, due to embolic dissemination of fungus infected thrombotic aortic material, can indicate correct diagnosis. Resumen Entre 49 casos autopsiados de paracoccidioidomicosis se encontraron 4 casos de aortitis fúngica. En 3 de ellos, trombosis suprayacentes provocaron trastornos circulatorios graves de las piernas; en 1 se desarrolló una necrosis intestinal y esplénica debido a embolías en las arterias correspondientes. Aparentemente metástasis fúngicas de la pared aórtica no son tan raras en la paracoccidioidomicosis, pero hasta la fecha observadas unicamente en Venezuela. Aparte de hallazgos pulmonares sospechosos, diseminaciones de úlceras dérmicas, cronologicamente y territorialmente limitadas a areas circulatorias circumscrip‐tas, pueden ayudar en el diagnóstico clínico. Se explican por la embolización de material trombótico infectado, precipitado sobre las alteraciones de la pared aórtica.

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Zusammenfassung Kurze Mitteilung eines Falles anurisdier subakuter diffuser Glomerulonephritis, vergesellschaftet mit septisch‐generalisierter Cryptococcose. Da Patientin wiederholt mit Haemodialyse behandelt wurde, mußte theoretisch an eine Pilzinfektion der Apparatur gedacht werden, ein Verdacht, der sich jedoch bei einer kulturellen Überprüfung nicht bestätigte. Resumen Información breve sobre un caso de glomerulonefritis difusa subaguda en fase anúrica asociada con una criptococcosis séptica generalizada. Considerando que la paciente fue tratada varias veces con hemodiálisis, existó teoricamente la posibilidad de la infección micótica del riñón artificial; sospecha no se confirmó en un examen de cultivo. Summary Brief information about a case of subacute diffuse glomerulonephritis in anuric phase, associated with generalized cryptococcosis. Taking into account that the patient was treated few times with hemodialysis, we thought in the possible infection of the artificial kidney by the fungus. However we were unable to demonstrate so by means of culture.