Background:
The transition metal complexes are derived from a natural biopolymer
which is a very potent material in various research areas of study.
Objective:
This study aims to show the preparation of ruthenium(III) complexes from chitosan Schiff
base ligand for effective application in antifungal studies.
Methods:
Chemical modification was carried out through a condensation reaction of chitosan with
some aromatic aldehydes, which resulted in the formation of a bidentate Schiff base ligand. The
Ru(III) complexes were prepared by complexation of ruthenium metal ion with bidentate ligands.
The series of Ru(III) complexes were characterized by Scanning Electron Microscope with Electron
dispersive X-ray (SEM-EDX) analysis, Powder XRD. The biopolymer-based transition metal complexes
have potential uses for their biological activities. The synthesized metal complexes were directed
for antifungal study by the disc diffusion method.
Results:
The antifungal study results showed that the transition metal complexes have significant antifungal
activities against some vital fungal pathogens such as Aspergillus flavus, Aspergillus niger,
Fusarium oxysporum, Penicillim chryogenum and Trigoderma veride.
Conclusion:
A chitosan biopolymer offers some peculiar features such as biodegradability, biocompatibility
etc., which are favorable for green synthesis of transition metal complexes through complexation
with bidentate ligands. These metal complexes possess good antifungal property due to
their chelation effect on micro-organisms.
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