Japan 5'-Alkyl(aryl)thio-5'-deoxynucleosides [alkyl(aryl)nucleoside sulphides] were prepared in high yields by the reaction of nucleosides with dialkyl or diaryl disulphides in the presence of tri-n-butylphosphine. The method is widely applicable to the synthesis of unsymmetrical sulphides.
Durch Umsetzung von entsprechenden Nucleosiden (II) mit entsprechenden Disul‐ ?den (II) in Gegenwart von Tributylphosphin werden in häufig hohen Ausb. die Nucleosid‐sulfide (III) erhalten.
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