Lactamase testing of clinical isolates of staphylococci may be performed in commercial broth microdilution minimum inhibitory concentration plates, using a chromogenic cephalosporin reagent directly in a well containing a noninhibitory concentration of a semisynthetic penicillin which serves as an inducer. A total of 115 staphylococcal isolates tested in 0.25 to 0.50 ,ug of methicillin per ml in Mueller-Hinton broth showed 100% correlation with 1-lactamase tests performed on Mueller-Hinton agar, using 1-,ug oxacillin disk as an inducer.
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