The bio-transformation of 3-β-hydroxy-5, 16-dien-pregnane-20-one (CDRI 80/574, 1) a novel antagonist of farnesoid X receptor (FXR) on hepatic membranes, with Aspergillus niger produced the oxidation products at C 3 and / or C 11 (compound 2 and 3) while the Aspergillus ochraeus promoted the oxidation at C 11 and / or C 15 (compound 4 and 5). The products were characterized using 2D-NMR spectroscopy.
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