A B S T R A C TAn experimental study has been carried out to investigate the tensile and flexural characterization of polymer hybrid composites made by reinforcing Jute, Pineapple leaf fiber, Copper foil and Aluminium foil into a epoxy resin. The weight fraction of composites was maintained at 40% fiber, 45% resin and l5% foil and the variation of mechanical properties such as tensile and flexural properties in each case were studied. The tensile strength was maximum in jute and pineapple composite. Further, the Flexural strength of the composite also maximum in jute and pineapple composite.
Objective: The objectives of the present study were to optimize and evaluate the ethosomal suspension of miconazole nitrate for the treatment of local and systemic fungal infections.
Methods: Miconazole topical formulation is prepared for better patient compliance and to reduce the dose of a drug. Miconazole nitrate ethosomes were prepared by the cold method using factorial designing with Ethanol(X1), IPA(Isopropyl alcohol)(X2), and Lecithin(X3) as Independent variables and % EE(Entrapment efficiency)(Y1) and % DR(drug release at 8th h)(Y2) was selected as responses.
Results: The results obtained in the design showed that there was no significant interaction among factors. The lecithin concentration had a positive response on % EE, while ethanol concentration and IPA had a positive effect. For % DR, Ethanol, and IPA showed a positive effect and Lecithin had a negative response. The formulation EM22 (3 ml X1,3 ml X2 and 300 mg of X3) characterized by high % EE(77.3 %) and optimum % DR(94.2%) and formulation EM6 (2 ml X1,2 ml X2 and 100 mg of X3) characterized by high % DR(97.32 %) and optimum % EE (74.8 %). EM22 was incorporated in the gel as it is showing more entrapment efficiency and compared with the marketed product for drug release.
Conclusion: From the result, it was concluded that formulated ethosomal suspension and optimized gel have more drug release than marketed formulation so that formulated suspension can be used for the preparation of antifungal gels, creams, ointments for sustained release.
In the present work, ZA-8 alloy is processed through centrifugal casting process at different rotational speed of the mould as 400 rpm, 600 rpm and 800 rpm. The effect of rotational speed of the mould on the microstructure and hardness are studied. It is observed that, at 600 rpm complete cast tube with fine microstructure is obtained and at 400 rpm, 800 rpm coarse and dendrite structure is been observed. Uniform hardness values are obtained at inner, middle and outer layer for the cast tube processed at 600 rpm compared to other cast tubes.
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