We performed a double-blind clinical study to determine the efficacy of nonwoven laparotomy drapes in which 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, an antimicrobial agent, was chemically bonded to the absorbent reinforcement surrounding the fenestration. The reinforcement portion of the surgical drape that contained the fenestration was segmented into four identical-appearing sections, two on each side of the fenestration. One segment on each side was antimicrobial. The locations of the treated segments were randomly varied. At the end of each operation, test strips were removed. Bacteria were harvested from each segment by mechanical agitation. Bacterial CFU were counted. There were 110 surgical cases in the study, including clean, clean contaminated, and contaminated procedures. Data analysis divided the cases into two distinct groups. Group 1 was composed of 59 cases in which less than 30 total CFU was recovered from the four test samples. The average duration of surgery for this group was 1.8 h. Group 2 was composed of 51 cases in which bacterial recovery was in excess of 30 CFU per procedure (range, 30 to 25,000 bacterial CFU). The average duration of surgery was 3.3 h. Bacterial reduction in the treated strips was 84%. The most common organisms identified on the laparotomy drapes were Staphylococcus epidermidis, S. hominis, and Micrococcus luteus. This study demonstrated that the reinforcement of a laparotomy drape is a reservoir for potential pathogens. It demonstrated that an organosilicon quaternary ammonium antimicrobial agent covalently bonded to the reinforcement reduced the number of potential pathogens surrounding the surgical incision by 84%, independent of the size of the bacterial challenge. * Corresponding author. t Julius Conn died during the preparation of this report. We dedicate this small token of our combined efforts to his memory.
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